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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Radiol. Nov 28, 2025; 17(11): 113701
Published online Nov 28, 2025. doi: 10.4329/wjr.v17.i11.113701
Published online Nov 28, 2025. doi: 10.4329/wjr.v17.i11.113701
Neuroimaging with photon-counting computed tomography: A review of clinical applications
Arosh S Perera Molligoda Arachchige, Gabriel Amorim Moreira Alves, Daniil Fedorov, Luca Cappellini, Federica Catapano, Marco Francone, Letterio S Politi, Department of Biomedical Sciences, Humanitas University, Pieve Emanuele 20072, Milan, Italy
Gaia Ressa, Riccardo Levi, Giovanni Savini, Marco Francone, Department of Radiology, IRCCS Humanitas Research Hospital, Rozzano 20089, Lombardy, Italy
Letterio S Politi, Department of Neuroradiology, IRCCS Humanitas Research Hospital, Rozzano 20089, Lombardy, Italy
Author contributions: Perera Molligoda Arachchige AS conceived, designed, and planned the review; Politi LS and Perera Molligoda Arachchige AS prepared and curated the figures; all authors contributed equally to the literature review, critical discussion, and revision of the manuscript draft written by Perera Molligoda Arachchige AS. All authors read and approved the final version of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Arosh S Perera Molligoda Arachchige, MD, Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele 20072, Milan, Italy. aroshshavinda.pereramolligodaarachchige@st.hunimed.eu
Received: September 1, 2025
Revised: October 11, 2025
Accepted: October 28, 2025
Published online: November 28, 2025
Processing time: 87 Days and 11.2 Hours
Revised: October 11, 2025
Accepted: October 28, 2025
Published online: November 28, 2025
Processing time: 87 Days and 11.2 Hours
Core Tip
Core Tip: Photon-counting computed tomography offers unprecedented spatial and spectral resolution in neuroimaging, enabling improved detection of subtle pathologies such as small vessels, cerebrospinal fluid leaks, and early ischemic changes, while reducing artifacts and radiation dose. Despite current challenges in protocol standardization, data handling, and integration of artificial intelligence-based noise reduction, photon-counting computed tomography holds strong potential to become a new standard in clinical neuroimaging.