Retrospective Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Radiol. Jul 28, 2024; 16(7): 256-264
Published online Jul 28, 2024. doi: 10.4329/wjr.v16.i7.256
Correlation between dose-volume parameters and rectal bleeding after 12 fractions of carbon ion radiotherapy for prostate cancer
Takashi Ono, Hiraku Sato, Yuya Miyasaka, Yasuhito Hagiwara, Natsuko Yano, Hiroko Akamatsu, Mayumi Harada, Mayumi Ichikawa
Takashi Ono, Hiraku Sato, Yasuhito Hagiwara, Natsuko Yano, Hiroko Akamatsu, Mayumi Harada, Mayumi Ichikawa, Department of Radiation Oncology, Faculty of Medicine, Yamagata University, Yamagata 990-9585, Japan
Yuya Miyasaka, Department of Heavy Particle Medical Science, Yamagata University Graduate School of Medical Science, Yamagata 990-9585, Japan
Author contributions: Ono T designed and performed the research and wrote present paper; Sato H designed and supervised the report; Miyasaka Y provided clinical advice; Hagiwara Y, Yano N, Akamatsu H, Harada M, and Ichikawa M contributed to data analysis.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the Faculty of Medicine at Yamagata University (approval number: 2023-51).
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written informed consent. When consenting to treatment, we also informed patients of the possibility of their use in research, and they agreed to this, so we do not believe it is necessary to obtain new consent for this study. For full disclosure, the details of the study are published on the home page of Faculty of Medicine at Yamagata University.
Conflict-of-interest statement: All authors report no relevant conflicts of interest for this article.
Data sharing statement: Data sharing is not applicable to this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: Https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Takashi Ono, MD, PhD, Doctor, Department of Radiation Oncology, Faculty of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan. abc1123513@gmail.com
Received: May 21, 2024
Revised: July 8, 2024
Accepted: July 10, 2024
Published online: July 28, 2024
Processing time: 63 Days and 21.9 Hours
Core Tip

Core Tip: This study identified the risk factors for rectal bleeding, including dose–volume parameters of 51.6 Gy [relative biological effectiveness (RBE)] in 12 fractions of carbon ion radiotherapy (CIRT) for prostate cancer. The cutoff values of D2cc = 46.46 Gy (RBE), V10 Gy (RBE) = 9.85 cc, and V20 Gy (RBE) = 7.00 cc were significant factors for the occurrence rate of grade 2 rectal bleeding. When planning CIRT for prostate cancer, the rate of rectal bleeding may decrease if these values are used.