Published online Nov 28, 2016. doi: 10.4329/wjr.v8.i11.857
Peer-review started: June 6, 2016
First decision: July 26, 2016
Revised: October 11, 2016
Accepted: October 22, 2016
Article in press: October 23, 2016
Published online: November 28, 2016
Processing time: 171 Days and 0.6 Hours
Diffusion-weighted imaging (DWI) of the liver can be performed using most commercially available machines and is currently accepted in routine sequence. This sequence has some potential as an imaging biomarker for fibrosis, tumor detection/characterization, and following/predicting therapy. To improve reliability including accuracy and reproducibility, researchers have validated this new technique in terms of image acquisition, data sampling, and analysis. The added value of DWI in contrast-enhanced magnetic resonance imaging was established in the detection of malignant liver lesions. However, some limitations remain in terms of lesion characterization and fibrosis detection. Furthermore, the methodologies of image acquisition and data analysis have been inconsistent. Therefore, researchers should make every effort to not only improve accuracy and reproducibility but also standardize imaging parameters.
Core tip: The current application of diffusion-weighted imaging (DWI) is reviewed. DWI has some potential as an imaging biomarker for fibrosis, tumor detection/characterization, and following/predicting therapy. However, some limitations remain in terms of lesion characterization and fibrosis detection. To improve reliability including accuracy and reproducibility, researchers have validated this new technique in terms of image acquisition, data sampling, and analysis.