Fixed vs weight-based heparin dosing in stable patients undergoing diagnostic coronary physiology studies

Table 1 Baseline characteristics, n (%)

	Total (n = 128)	Fixed dose (n = 78)	Weight-based (n = 50)
Age (mean ± SD), years	67 ± 11	68 ± 11	66 ± 11
Gender
Male	87 (68)	45 (58)	42 (84)
Female	41 (32)	33 (42)	8 (16)
BMI (mean ± SD, kg/m2)	28.97 ± 5.1	28.23 ± 5	30 ± 5
Underweight	1 (0.8)	1 (1.3)	0 (0)
Normal	28 (21.9)	19 (24.4)	9 (18)
Overweight	48 (37.5)	31 (39.7)	17 (34)
Obese	51 (39.8)	27 (34.6)	24 (48)
Weight (mean ± SD, kg)	85.1 ± 17.8	79.9 ± 15.8	93.4 ± 17.7
Medical history
Chronic kidney disease (eGFR < 60)	3 (2)	2 (3)	1 (2)
Chronic liver disease	4 (3)	3 (4)	1 (2)
Bleeding diathesis	0 (0)	0 (0)	0 (0)
Thrombocytopenia (< 100000)	0 (0)	0 (0)	0 (0)
Anticoagulation (DOAC or warfarin)	15 (12)	10 (13)	5 (10)
On anti-platelets	97 (76)	58 (74)	39 (78)
Indication
FFR	114 (89)	64 (82)	50 (100)
Microvascular	14 (11)	14 (18)	0 (0)
Access site
Radial	117 (91)	71 (91)	46 (92)
Femoral	11 (9)	7 (9)	4 (8)
Median heparin dose IU, median (IQR)		5000 (5000, 5000)	8000 (7000, 9000)
BARC bleeding score
0 (no bleeding)	110 (85)	65 (83.3)	44 (88)
1	18 (14)	12 (15.4)	6 (12)
2	1 (1)	1 (1.3)	0 (0)
3	0 (0)	0 (0)	0 (0)
4	0 (0)	0 (0)	0 (0)
5	0 (0)	0 (0)	0 (0)
Radial artery occlusion	0 (0)	0 (0)	0 (0)
Stroke	0 (0)	0 (0)	0 (0)
Post-procedure MI	0 (0)	0 (0)	0 (0)
Length of stay days, median (IQR)	1 (1, 4)	1 (1, 3)	1 (1, 4)

BMI: Body mass index; eGFR: Estimated glomerular filtration rate; DOAC: Direct acting oral anticoagulants; FFR: Fractional flow reserve; IQR: Interquartile range; BARC: Bleeding Academic Research Consortium.

Table 2 Logistic regression analysis for bleeding predictors

Predictor	Unadjusted OR (95%CI)	P value	Adjusted OR (95%CI)	P value
Sex	0.60 (0.20-1.89)	0.424
Access site	2.35 (0.36-11.19)	0.210	2.09 (0.42-8.22)	0.318
Antiplatelet use	3.06 (0.66-28.95)	0.158	2.90 (0.76-19.1)	0.713
Anticoagulant use	0.87 (0.09-4.41)	1

OR: Odds ratio; CI: Confidence interval.