©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Jan 26, 2026; 18(1): 112321
Published online Jan 26, 2026. doi: 10.4330/wjc.v18.i1.112321
Published online Jan 26, 2026. doi: 10.4330/wjc.v18.i1.112321
Fixed vs weight-based heparin dosing in stable patients undergoing diagnostic coronary physiology studies
Kristoffer Ken Ralota, Deniz Tuncer, Nay Min Htun, Rohit Samuel, Vivek Gupta, Robert Lew, Jamie Layland, Department of Cardiology, Peninsula Health, Frankston 3199, Victoria, Australia
Jamie Layland, Department of Medicine, Peninsula Clinical School, Monash University, Frankston 3199, Victoria, Australia
Author contributions: Ralota KK and Tuncer D contributed to data collection and draft the manuscript; Ralota KK checked the data, its content, flow, and narrative, enacted the necessary revisions of the manuscript, preparation and submission of the current version of the manuscript; Layland J is the senior researcher who conceptualized the study, helped in vetting of related literature, and supervised the entire process. Htun NM, Samuel R, Gupta V, Lew R, and Layland J contributed to review the manuscript. All authors have read and approved the final manuscript.
Institutional review board statement: The study was approved by our institutional Human Research Ethics Committee with approval number LNR/107040/PH-2024.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: Data can be requested from either the first author Ralota KK (kralota@phcn.vic.gov.au) or the senior author Layland J (jlayland@phcn.vic.gov.au).
Corresponding author: Jamie Layland, MD, PhD, FRACP, MRCP, Professor, Senior Researcher, Department of Cardiology, Peninsula Health and Department of Medicine, Peninsula Clinical School, Monash University, 2 Hastings Road, Frankston 3199, Victoria, Australia. jlayland@phcn.vic.gov.au
Received: July 24, 2025
Revised: September 24, 2025
Accepted: December 8, 2025
Published online: January 26, 2026
Processing time: 176 Days and 5.2 Hours
Revised: September 24, 2025
Accepted: December 8, 2025
Published online: January 26, 2026
Processing time: 176 Days and 5.2 Hours
Core Tip
Core Tip: This study explores the safety and efficacy of fixed-dose vs weight-based unfractionated heparin dosing during diagnostic coronary physiology procedures. Among 128 patients, fixed-dose 5000 IU unfractionated heparin was associated with similarly low rates of bleeding and no thrombotic events compared to weight-based dosing. These findings suggest that a fixed-dose approach may be a safe and practical alternative in low-risk, physiology-only settings. The results may inform future research and support consideration of simplified anticoagulation strategies in stable patients undergoing diagnostic coronary physiology assessments.