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World J Cardiol. Apr 26, 2026; 18(4): 117929
Published online Apr 26, 2026. doi: 10.4330/wjc.v18.i4.117929
Published online Apr 26, 2026. doi: 10.4330/wjc.v18.i4.117929
Daming capsule combined with SGLT2i confers protection against diabetes with myocardial ischemia/reperfusion injury induced ferroptosis via AMPK
Xian Yang, Yong-Ting Zhao, Han Liu, Ru-Xin Wang, Liang-Yan Wu, Hao-Wen Ye, Yun Wen, Jia-Xin Wang, Mei-Xin Yu, Cai-Xia Ma, Li-Hong Wang, Department of Endocrinology and Metabolism, The First Affiliated Hospital of Jinan University, Guangzhou 510630, Guangdong Province, China
Xian Yang, National Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology, Ministry of Education, and Department of Metabolism and Endocri
Xiao-Fang Zhang, Li-Hong Wang, Guangzhou Key Laboratory of Basic and Translational Research on Chronic Diseases, Jinan University, Guangzhou 510630, Guangdong Province, China
Co-first authors: Xian Yang and Yong-Ting Zhao.
Co-corresponding authors: Xiao-Fang Zhang and Li-Hong Wang.
Author contributions: Wang LH, Zhang XF and Yang X contributed to the conception and designed the research; Yang X, Liu H, Wang RX performed the experiments; Wu LY, Zhao YT, Ye HW, Wen Y, Wang JX, Yu MX and Ma CX analyzed the data; Yang X wrote the manuscript; Wang LH, Zhang XF and Zhao YT revised the manuscript and confirmed the final draft with Yang X; Yang X and Zhao YT have made crucial and indispensable contributions towards the completion of the project and thus qualified as the co-first authors of the paper; Zhang XF and Wang LH have played important and indispensable roles in the manuscript preparation as the co-corresponding authors; all authors approved the submitted version.
Supported by Talent Introduction Funding Project of the First Affiliated Hospital of Jinan University, No. 808026; Guangdong Medical Science and Technology Research Foundation, No. B2023119; Administration of Traditional Chinese Medicine of Guangdong Province, China, No. 20251082; and Guangdong Basic and Applied Basic Research Foundation, No. 2023A1515110934.
Institutional animal care and use committee statement: All experimental procedures followed the Guidelines for the Care and Use of Laboratory Animals of Jinan University and were approved by the Ethics Committees of Jinan University (No. IACUC-20220512-06).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: The data analyzed during the research can be obtained from the authors on reasonable request.
Corresponding author: Li-Hong Wang, Department of Endocrinology and Metabolism, The First Affiliated Hospital of Jinan University, No. 613 Huangpu Avenue West, Guangzhou 510630, Guangdong Province, China. lihongwang1688@jnu.edu.cn
Received: December 22, 2025
Revised: January 12, 2026
Accepted: March 12, 2026
Published online: April 26, 2026
Processing time: 116 Days and 12.7 Hours
Revised: January 12, 2026
Accepted: March 12, 2026
Published online: April 26, 2026
Processing time: 116 Days and 12.7 Hours
Core Tip
Core Tip: This study demonstrated the important role of ferroptosis in diabetes mellitus (DM) with myocardial ischemia-reperfusion (I/R) injury. For the first time, we advocated for an integrated Chinese and Western medicine approach to treating DM with I/R. Daming capsule and sodium-dependent glucose transporters 2 inhibitor reduced lipid peroxidation and iron deposition synergistically via adenosine monophosphate-activated protein kinase, thereby inhibiting ferroptosis and improving cardiac function.