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World J Cardiol. Mar 26, 2026; 18(3): 116661
Published online Mar 26, 2026. doi: 10.4330/wjc.v18.i3.116661
Published online Mar 26, 2026. doi: 10.4330/wjc.v18.i3.116661
Prognostic significance of vascular endothelial dysfunction in patients with vasospastic angina
Hiroki Teragawa, Yu Hashimoto, Akane Tsuchiya, Shuichi Nomura, Department of Cardiovascular Medicine, Futabanosato Prefectural Hospital, Hiroshima 732-0057, Japan
Author contributions: Teragawa H drafted and revised the manuscript; Hashimoto Y, Tsuchiya A, and Nomura S acquired the data. All authors reviewed and approved the final version.
Institutional review board statement: This study was reviewed and approved by the Futabanosato Prefectural Hospital (formerly JR Hiroshima Hospital) Institutional Review Board (approval No. 2024-38).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data beyond those presented in this paper are available.
Corresponding author: Hiroki Teragawa, MD, PhD, Department of Cardiovascular Medicine, Futabanosato Prefectural Hospital, 3-1-36 Futabanosato, Higashi-ku, Hiroshima 732-0057, Japan. hiroki-teragawa@jrhh.or.jp
Received: November 17, 2025
Revised: December 9, 2025
Accepted: January 23, 2026
Published online: March 26, 2026
Processing time: 126 Days and 10.2 Hours
Revised: December 9, 2025
Accepted: January 23, 2026
Published online: March 26, 2026
Processing time: 126 Days and 10.2 Hours
Core Tip
Core Tip: Vasospastic angina usually carries a favorable prognosis with lifestyle modification and vasodilator therapy, but reliable noninvasive prognostic markers remain scarce. This study examined whether vascular endothelial dysfunction, assessed by brachial artery flow-mediated dilation, could serve as a marker. Patients with lower flow-mediated dilation values (< 3.7%) had worse outcomes, indicating that vascular endothelial dysfunction is associated with poorer prognosis in vasospastic angina. These findings highlight the potential role of endothelial function assessment in risk stratification, warranting further validation in larger studies.