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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Sep 26, 2025; 17(9): 110061
Published online Sep 26, 2025. doi: 10.4330/wjc.v17.i9.110061
Published online Sep 26, 2025. doi: 10.4330/wjc.v17.i9.110061
Coronary computed tomography angiography vs stress testing for stable angina evaluation: Diagnostic and prognostic superiority
Vinay Gundareddy, Internal Medicine, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, United States
Shivam Singla, Internal Medicine, Tidal Health Peninsula Regional, Salisbury, NC 21801, United States
Jupalle Mounika, Internal Medicine, Kurnool Medical College, Kurnool 518002, Andhra Pradesh, India
Okello Owona, Internal Medicine, Ministry of Health, Lusaka 10101, Zambia
Bhavna Singla, Internal Medicine, Erie County Medical Center, Buffalo, NY 14215, United States
Taranpreet Singh, Internal Medicine, Mahatma Gandhi Mission Medical College and Hospital, Navi Mumbai 410209, Maharashtra, India
Sidra Anwar, Internal Medicine, Shaikh Zayed Hospital, Lahore 54600, Punjab, Pakistan
Vignesh Ramachandran, Internal Medicine, Melmaruvathur Adhiparasakthi Institute of Medical Sciences and Research, Melmaruvathur 603319, Tamil Nādu, India
Hikmat Ullah, Internal Medicine, Allama Iqbal Medical College, Lahore 54550, Punjab, Pakistan
Shabbir Mazari, Internal Medicine, Kabul Medical University, Kabul 100306, Afghanistan
Author contributions: Gundareddy V, Singla S, Mounika J, Owona O, Singla B and Singh T designed the research study; Singla S, Mounika J, Anwar S and Ramachandran V performed the research and contributed to data extraction and synthesis; Ullah H, Mazari S and Ramachandran V contributed to critical editing, formatting, and quality check; Gundareddy V, Owona O, and Mounika J analyzed the data and contributed to interpretation of findings; Gundareddy V, Singla B and Singh T wrote the manuscript and responded to reviewer comments. All authors have read and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shabbir Mazari, Consultant, Internal Medicine, Kabul Medical Univer
Received: May 28, 2025
Revised: June 18, 2025
Accepted: August 27, 2025
Published online: September 26, 2025
Processing time: 111 Days and 22.5 Hours
Revised: June 18, 2025
Accepted: August 27, 2025
Published online: September 26, 2025
Processing time: 111 Days and 22.5 Hours
Core Tip
Core Tip: This systematic review compares coronary computed tomography angiography (CCTA) and stress testing in patients with stable angina. Analyzing five randomized controlled trials, the study highlights the superior diagnostic accuracy and prognostic value of CCTA. CCTA was associated with fewer unnecessary invasive procedures, better event-free survival, and more appropriate revascularization decisions compared to stress testing modalities. These findings support the integration of CCTA into first-line diagnostic pathways for intermediate-risk patients, promoting earlier diagnosis and optimized patient management.