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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Dec 26, 2025; 17(12): 112389
Published online Dec 26, 2025. doi: 10.4330/wjc.v17.i12.112389
Published online Dec 26, 2025. doi: 10.4330/wjc.v17.i12.112389
Cardiac sarcoidosis with a twist - active and fibrotic sarcoid with antiphospholipid positivity: A case report
Sujoy Khasnavis, Department of Medicine, Jacobi North Central Bronx Hospital, Bronx, NY 10467, United States
Sakul Sakul, Marko Novakovic, Paulus Adinugraha, Davendra Mehta, Department of Cardiology, Mount Sinai Morningside, New York, NY 10025, United States
Author contributions: Khasnavis S conceptualized the topic; Khasnavis S and Sakul wrote the manuscript; Novakovic M prepared relevant images for the manuscript; Sakul and Adinugraha P edited the manuscript; Mehta D supervised the preparation of the manuscript.
Informed consent statement: Informed consent was obtained from the patient described in this case report.
Conflict-of-interest statement: All authors declare no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sujoy Khasnavis, Researcher, Department of Medicine, Jacobi North Central Bronx Hospital, 111 East 210th Street, Bronx, NY 10467, United States.
Received: July 31, 2025
Revised: September 7, 2025
Accepted: November 7, 2025
Published online: December 26, 2025
Processing time: 147 Days and 8.5 Hours
Revised: September 7, 2025
Accepted: November 7, 2025
Published online: December 26, 2025
Processing time: 147 Days and 8.5 Hours
Core Tip
Core Tip: Fibrotic cardiac sarcoidosis with concomitant active systemic sarcoidosis and antiphospholipid positivity are unreported in literature. The various systemic manifestations of this combination of diseases require intricate medical management. As traditional immunosuppressants have limited utility in burnt sarcoidosis and concurrent antiphospholipid positivity raises risks for thromboembolic disease, essential management strategies include close monitoring of antiphospholipid disease and timely tapering from thrombotic to non-thrombotic immunosuppressants.