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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Dec 26, 2025; 17(12): 112126
Published online Dec 26, 2025. doi: 10.4330/wjc.v17.i12.112126
Published online Dec 26, 2025. doi: 10.4330/wjc.v17.i12.112126
Predictors of life-threatening events in adult patients with left ventricular noncompaction
Olga V Blagova, Nadezhda V Varionchik, Ekaterina V Pavlenko, Yulia A Lutokhina, Division of Internal Medicine No. 1, Department of Cardiology, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119048, Russia
Vsevolod P Sedov, Division of Radiology and Radiation Therapy, Department of Cardiology, Functional Diagnostics and Ultrasound, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119048, Russia
Author contributions: Blagova OV designed and supervised the study; Blagova OV, Varionchik NV, and Lutokhina YA conducted the study; Varionchik NV and Lutokhina YA wrote the original draft of the manuscript; Pavlenko EV contributed to the data analysis; Sedov VP provided clinical advice. All authors read and approved the final version of the manuscript.
Institutional review board statement: The study was approved by the Ethics Committee of the I.M. Sechenov First Moscow State Medical University.
Informed consent statement: All patients signed a voluntary informed consent to participate in the study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: Please contact the corresponding author for details.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yulia A Lutokhina, MD, PhD, Professor, Division of Internal Medicine No. 1, Department of Cardiology, I.M. Sechenov First Moscow State Medical University (Sechenov University), 8-2 Trubetskaya Street, Moscow 119048, Russia.
Received: July 18, 2025
Revised: September 17, 2025
Accepted: October 30, 2025
Published online: December 26, 2025
Processing time: 159 Days and 13.6 Hours
Revised: September 17, 2025
Accepted: October 30, 2025
Published online: December 26, 2025
Processing time: 159 Days and 13.6 Hours
Core Tip
Core Tip: Left ventricular noncompaction (LVNC) is associated with a high risk of thrombosis/embolism and arrhythmias. We investigated the predictors of these types of events in 125 patients with LVNC over an average follow-up of 14 months. Following electrocardiography, echocardiography, 24-hour electrocardiogram monitoring, cardiac magnetic resonance imaging, cardiac computed tomography, genetic testing, myocardial morphological examination, and laboratory examination, the acquired data were analyzed. Frequent premature ventricular contractions, non-sustained ventricular tachycardia, low QRS voltage, and signs of systolic dysfunction must be considered for risk assessment in patients with LVNC.