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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Nov 26, 2025; 17(11): 110339
Published online Nov 26, 2025. doi: 10.4330/wjc.v17.i11.110339
Published online Nov 26, 2025. doi: 10.4330/wjc.v17.i11.110339
Role of SOX9 in cardiovascular diseases: Evidence today
Angat Naresh Chadha, Han Cheng, Jing Yang, Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China
Angat Naresh Chadha, Department of Cardiovascular and Thoracic Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Han Cheng, Medical College of Soochow University, Soochow University, Suzhou 215006, Jiangsu Province, China
Author contributions: Chadha AN conducted original draft preparation; Yang J was responsible for the writing, review and editing of the first draft; Chadha AN, Cheng H, and Yang J contributed to the study conception and design, commented on previous versions of the manuscript; and all authors read and approved the final manuscript.
Supported by the National Natural Science Foundation of China, No. 82200353; the Jiangsu Province Double Innovation Doctoral Program, No. JSSCBS20221948; the Suzhou Gusu Health Talent Program, No. (2022)043; the Suzhou Gusu Health Talent Plan Talent Research Project, No. GSWS2022014; the Suzhou Science and Technology Innovation Policy Funding Project, the Jiangsu Province College Students’ Innovation and Entrepreneurship Training Program Project, No. 202410285087Z; the Multi-Center Clinical Research Project for Major Diseases in Suzhou, No. DZXYJ202302; and “Bo Xi” Talent Casting Plan of the First Affiliated Hospital of Soochow University.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jing Yang, PhD, Department of Cardiology, The First Affiliated Hospital of Soochow University, No. 899 Pinghai Road, Suzhou 215006, Jiangsu Province, China. jingyang_cardio@163.com
Received: June 5, 2025
Revised: July 19, 2025
Accepted: September 23, 2025
Published online: November 26, 2025
Processing time: 169 Days and 23.6 Hours
Revised: July 19, 2025
Accepted: September 23, 2025
Published online: November 26, 2025
Processing time: 169 Days and 23.6 Hours
Core Tip
Core Tip: This article synthesizes evidence revealing the dual roles of SRY-related high-mobility group box 9 (SOX9) in cardiovascular biology. Crucially, SOX9 is indis