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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Nov 26, 2025; 17(11): 110178
Published online Nov 26, 2025. doi: 10.4330/wjc.v17.i11.110178
Published online Nov 26, 2025. doi: 10.4330/wjc.v17.i11.110178
Prehospital aspirin use is associated with improved clinical outcomes in pulmonary embolism: A retrospective case-control study
Mithil Gowda Suresh, Harinivaas Shanmugavel Geetha, Akshaya Sekar, Sushmita Prabhu, Jennifer Sargent, George M Abraham, Department of Internal Medicine, Saint Vincent Hospital, Worcester, MA 01608, United States
Safia Mohamed, Department of Medicine and Surgery, University of Massachusetts Chan Medical School-Baystate Medical Center, Springfield, MA 01199, United States
Juniali Hatwal, Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India
Akash Batta, Bishav Mohan, Department of Cardiology, Dayanand Medical College and Hospital, Ludhiana 141001, Punjab, India
Author contributions: Suresh MG, Geetha HS, and Prabhu S contributed equally to study conception, data collection, and initial manuscript drafting; Mohamed S and Sekar A and participated in statistical analysis, chart review, and results interpretation; Sargent J, Abraham GM, Hatwal J, Batta A, and Mohan B supervised the project, provided critical revisions, and approved the final manuscript; and all authors contributed to data interpretation, revised the manuscript critically for important intellectual content, and approved the final version to be submitted.
Institutional review board statement: This study was approved by the Medical Ethics Committee of Saint Vincent Hospital, approval No. IRB#2022-069.
Informed consent statement: The need for informed consent was waived due to the retrospective nature of the study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: Data will be shared on reasonable request by the journals board.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Akash Batta, MD, Associate Professor, Department of Cardiology, Dayanand Medical College and Hospital, Tagore Nagar, Civil Lines, Ludhiana 141001, Punjab, India. akashbatta02@gmail.com
Received: June 3, 2025
Revised: June 17, 2025
Accepted: October 21, 2025
Published online: November 26, 2025
Processing time: 174 Days and 23 Hours
Revised: June 17, 2025
Accepted: October 21, 2025
Published online: November 26, 2025
Processing time: 174 Days and 23 Hours
Core Tip
Core Tip: In this retrospective case-control study, we demonstrate that patients with pulmonary embolism who were on aspirin prior to hospitalization had significantly lower incidence of right ventricular strain, intensive care unit admission, shock, and mortality. These results suggest a protective role of aspirin in pulmonary embolism pathophysiology and highlight the need for further prospective validation.