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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Oct 26, 2025; 17(10): 109961
Published online Oct 26, 2025. doi: 10.4330/wjc.v17.i10.109961
Published online Oct 26, 2025. doi: 10.4330/wjc.v17.i10.109961
Role of polymorphisms and microRNA levels in predicting cardiovascular events in patients with acute myocardial infarction
Toan Hoang Ngo, Son Kim Tran, Department of Internal Medicine, Faculty of Medicine, Can Tho University of Medicine and Pharmacy, Can Tho 90000, Viet Nam
Co-corresponding authors: Toan Hoang Ngo and Son Kim Tran.
Author contributions: Ngo TH and Tran SK conceptualized the study and drafted, reviewed and edited the manuscript; the equal contributions of Ngo TH and Tran SK underlie their responsibility as co-corresponding authors, and both agree to the published version of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Son Kim Tran, Department of Internal Medicine, Faculty of Medicine, Can Tho University of Medicine and Pharmacy, No 179 Nguyen Van Cu Street, Tan An Ward, Can Tho 90000, Viet Nam. tkson@ctump.edu.vn
Received: May 27, 2025
Revised: June 14, 2025
Accepted: September 17, 2025
Published online: October 26, 2025
Processing time: 151 Days and 2.8 Hours
Revised: June 14, 2025
Accepted: September 17, 2025
Published online: October 26, 2025
Processing time: 151 Days and 2.8 Hours
Core Tip
Core Tip: Acute myocardial infarction (AMI) remains a leading cause of morbidity and mortality worldwide, and traditional biomarkers offer limited prognostic value. This review highlights the emerging significance of circulating microRNAs (miRNAs)-particularly miR-150, miR-208, miR-26a, and miR-483-5p and genetic polymorphisms such as rs2910164 in miR-146a in predicting AMI risk and major adverse cardiovascular events. These biomarkers regulate inflammation and endothelial dysfunction through key pathways, nuclear factor-kappaB, and nterleukin-1 receptor/toll-like receptors signaling. Integrating miRNA profiling with clinical assessment may enhance early diagnosis and enable personalized risk stratification in AMI patients.