Fan ZX, Liang N, Lu JF, Liu GZ. Neurocardiology - from basics to clinic. World J Cardiol 2025; 17(11): 109941 [DOI: 10.4330/wjc.v17.i11.109941]
Corresponding Author of This Article
Guang-Zhi Liu, MD, Professor, Department of Neurology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences, No. 11 Shixing Street, Shijingshan District, Beijing 100144, China. guangzhi2002@hotmail.com
Research Domain of This Article
Neurosciences
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Cardiol. Nov 26, 2025; 17(11): 109941 Published online Nov 26, 2025. doi: 10.4330/wjc.v17.i11.109941
Neurocardiology - from basics to clinic
Ze-Xin Fan, Na Liang, Jian-Feng Lu, Guang-Zhi Liu
Ze-Xin Fan, Department of Neurology, The Second Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China
Na Liang, Department of Emergency Medicine, The Second Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China
Jian-Feng Lu, Department of Neurology, Qingdao Hiser Hospital Affiliated of Qingdao University, Qingdao 266000, Shandong Province, China
Guang-Zhi Liu, Department of Neurology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Beijing 100144, China
Author contributions: Fan ZX, Liang N, and Lu JF contributed to the manuscript draft, schematic illustrations; Liu GZ conceptualized the project, supervised the research, contributed substantially to the manuscript draft, and performed major revisions; and all authors thoroughly reviewed and endorsed the final manuscript.
Supported by the Fundamental Research Program of Shanxi Province, No. 202403021212275.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Guang-Zhi Liu, MD, Professor, Department of Neurology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences, No. 11 Shixing Street, Shijingshan District, Beijing 100144, China. guangzhi2002@hotmail.com
Received: May 27, 2025 Revised: June 19, 2025 Accepted: October 9, 2025 Published online: November 26, 2025 Processing time: 179 Days and 1.6 Hours
Abstract
Neurocardiology is an interdisciplinary field that studies the interactions between the nervous and cardiovascular systems, encompassing research across the entire spectrum, from molecular mechanisms to clinical diagnosis and treatment. The disease types in neurocardiology include several major categories: Involvement of the nervous and cardiovascular systems caused by common factors, involvement of the cardiovascular system caused by neuropsychiatric abnormalities, and involvement of the nervous system caused by cardiovascular abnormalities. Routine and special examinations are needed during the diagnostic process. The simultaneous management of brain and heart conditions is the core strategy, which advocates multidisciplinary collaboration, communication, and interaction. Herein, we review studies on the pathophysiological mechanisms, clinical manifestations, and new advances in diagnosis and treatment in the field of neurocardiology, particularly the latest research progress of traditional Chinese medicine, and further propose the construction of an integrated healthcare service system for future research.
Core Tip: As a burgeoning medical science, neurocardiology is an interdisciplinary field built on the foundations of neurology and cardiology and dedicated to studying the interactions between the nervous, mental, and psychological systems; cardiovascular diseases; and circulatory function. However, it remains in its initial developmental stages in terms of pathophysiological mechanisms, diagnosis and treatment. Precision therapy in neurocardiology is expected to become a future trend. The present review focuses on the basis of neurocardiac interactions, auxiliary examinations, traditional Chinese medicine, and multidisciplinary treatment in the research field of neurocardiology. Finally, we further proposed the construction of an integrated medical and health service system for future research.
