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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Biol Chem. Dec 5, 2025; 16(4): 111156
Published online Dec 5, 2025. doi: 10.4331/wjbc.v16.i4.111156
Published online Dec 5, 2025. doi: 10.4331/wjbc.v16.i4.111156
Association between Alzheimer's disease and Porphyromonas gingivalis products in murine models: A systematic review
Karen L Ochoa, Amy G Heredia, Camila C Piedra, Reymonth J Arias, Bengy J Ortiz, Jose A Dominguez-Gortaire, Facultad de Ciencias Biológicas, Universidad Central del Ecuador, Quito 170403, Pichincha, Ecuador
Jose A Dominguez-Gortaire, Facultad de informática, Universidade de Coruña, A Coruna 15008, Galicia, Spain
Jose A Dominguez-Gortaire, Facultad de Odontología, University of Ecuador, Quito 170902, Ecuador
Author contributions: Ochoa KL contributed to conceptualization, methodology, formal analysis, data curation, writing–original draft; Heredia AG contributed to investigation, resources, data curation, writing–review and editing; Piedra CC contributed to investigation, validation, visualization, writing–review and editing; Arias RJ contributed to software, data curation, formal analysis, figure preparation; Ortiz BJ contributed to methodology, supervision, validation, writing–review and editing; Dominguez-Gortaire JA contributed to conceptualization, supervision, project administration, writing–original draft, final approval of the version to be published.
Conflict-of-interest statement: The authors declare that they have no commercial or financial relationships that could be construed as a potential conflict of interest. No competing interests exist regarding the publication of this manuscript.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jose A Dominguez-Gortaire, Professor, Facultad de Ciencias Biológicas, Universidad Central del Ecuador, Av. Yaguachi y Numa Pompillo, Quito 170403, Pichincha, Ecuador. jadominguezg@uce.edu.ec
Received: June 24, 2025
Revised: July 11, 2025
Accepted: October 22, 2025
Published online: December 5, 2025
Processing time: 163 Days and 13.4 Hours
Revised: July 11, 2025
Accepted: October 22, 2025
Published online: December 5, 2025
Processing time: 163 Days and 13.4 Hours
Core Tip
Core Tip: This review shows the role of Porphyromonas gingivalis (P. gingivalis)-derived products in Alzheimer's disease-like pathology in murine models. Lipopolysaccharides and gingipains were the most implicated bacterial factors, activating glial cells and proinflammatory pathways. These interactions resulted in β-amyloid accumulation, tau hyperphosphorylation, and cognitive impairment. Our analysis highlights the importance of chronic oral infection in the progression of Alzheimer's disease and supports P. gingivalis treatment as a potential preventive strategy.