Associations of clinical indexes and prognosis with gut-vascular barrier damage in patients with intestinal obstruction

Table 1 Demographic and biochemical characteristics between intestinal obstruction and control patients

Variables	IO group (n = 42)	Control group (n = 42)	P value
Age (years)	59.1 (45.5-72.7)	58.7 (45.8-71.6)	0.92
Male, n (%)	22 (52.3)	19 (45.2)	0.51
BMI (kg/m2)	21.4 (18.6-24.2)	22.3 (19.5-25.1)	0.14
HR (bpm)	83.5 (81.8-91.5)	77.0 (68.0-88.5)	0.03
SBP (mmHg)	117.0 (111.0-125.5)	125.5 (115.5- 133.5)	0.09
DBP (mmHg)	76.0 (71.0-82.0)	74.0 (69.8-80.3)	0.06
SPO2 (%)	100 (100-100)	100 (99-100)	0.59
ALT (U/L)	13.5 (9.0-25.0)	12.0 (9.0-17.3)	0.01
AST (U/L)	21.5 (16.8-35.5)	17.5 (15.0-20.2)	< 0.01
LDH (U/L)	208.5 (178.5-259.0)	180.0 (156.0-202.5)	0.02
ALP (U/L)	73.0 (55.5-89.0)	79.0 (67.0-93.0)	0.31
CHE (U/L)	5453.5 (3977.3-6092.0)	6973.0 (6071.3-7705.3)	< 0.01
TBIL (μmol/L)	12.8 (7.9-17.0)	9.8 (8.1-13.5)	0.04
DBIL (μmol/L)	1.5 (0.0-3.0)	1.6 (1.2-2.3)	0.59
IBIL (μmol/L)	8.7 (5.4-11.7)	8.0 (6.5-10.9)	0.61
BUN (mmol/L)	4.3 (3.0-5.6)	4.7 (3.5-5.8)	0.82
CREA (μmol/L)	62.5 (48.7-90.5)	67.5 (55.8-88.3)	0.34
CRP (mg/L)	20.8 (8.0-58.3)	3.2 (1.7-5.9)	< 0.01
WBC (109/L)	7.4 (5.9-9.3)	6.1 (5.0-6.8)	< 0.01
NEUT%	0.7 (0.6-0.8)	0.6 (0.5-0.7)	0.27
LY%	0.2 (0.1-0.3)	0.3 (0.2-0.4)	< 0.01
NEUT (109/L)	5.2 (3.5-6.8)	3.6 (2.7-4.5)	< 0.01
LY (109/L)	1.3 (0.8-1.7)	1.7 (1.4-2.1)	< 0.01
Laparotomy, n (%)	16 (38.1)	3 (7.14)	0.001
Tissue sample: Colon, n (%)	24 (57.1)	28 (66.7)	0.37

BMI: Body mass index; HR: Heart rate; SBP: Systolic blood pressure; DBP: Diastolic blood pressure; SPO₂: Pulse oxygen saturation; ALT: Alanine transaminase; AST: Aspartate aminotransferase; LDH: Lactate dehydrogenase; ALP: Alkaline phosphatase; CHE: Cholinesterase; TBIL: Total bilirubin; DBIL: Direct bilirubin; BUN: Blood urea nitrogen; CREA: Creatinine; CRP: C-reactive protein; WBC: White blood cell; NEUT: Neutrophil; LY: Lymphocyte.

Table 2 Correlations of PV1 with prognosis among patients with intestinal obstruction

Variables	OR (univariate)	P value	OR (multivariate)1	P value
Complications	1.23	0.02	1.21	0.04
Mortality	0.98	0.15	0.98	0.11

¹Adjusted for age, sex and body mass index.

OR: Odds ratio.

Table 3 Comparison of complications and mortality between PV1-high and PV1-low sub-group among intestinal obstruction patients, n (%)

Variables	PV1-high sub-group (n = 10)	PV1-low sub-group (n = 10)	P value
Complications	4 (40)	0 (0)	0.09
Mortality	2 (20)	0 (0)	0.47