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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Dec 27, 2025; 17(12): 111041
Published online Dec 27, 2025. doi: 10.4240/wjgs.v17.i12.111041
Published online Dec 27, 2025. doi: 10.4240/wjgs.v17.i12.111041
Associations of clinical indexes and prognosis with gut-vascular barrier damage in patients with intestinal obstruction
Hu-Fei Zhang, Yi-Nan Zhang, Hui Peng, Xu-Yu Zhang, Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China
Yi Guo, Xiao-Jun Chen, Department of Anesthesiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China
Zi-Meng Liu, Department of Critical Care Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China
Co-first authors: Hu-Fei Zhang and Yi Guo.
Co-corresponding authors: Zi-Meng Liu and Xu-Yu Zhang.
Author contributions: Zhang HF and Guo Y contribute equally to this study as co-first authors; Liu ZM and Zhang XY contribute equally to this study as co-corresponding authors; Zhang HF and Guo Y helped design and perform the studies and write the manuscript; Chen XJ helped perform the studies; Zhang YN helped perform the studies; Peng H helped analyze the data; Liu ZM helped generate the concept of the studies and write the manuscript; Zhang XY helped generate the concept of the studies and write the manuscript.
Supported by National Natural Science Foundation of China, No. 82072204 and No. 81701874; and Natural Science Foundation of Guangdong Province, China, No. 2021A1515010990 and No. 2025A1515012493.
Institutional review board statement: This study was approved by the Ethic Committee of The First Affiliated Hospital of Sun Yat-sen University, No.[2021]810.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: There is no conflict of interest.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xu-Yu Zhang, MD, PhD, Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, No. 58 Zhongshan 2th Road, Guangzhou 510080, Guangdong Province, China. zhangxuy@mail.sysu.edu.cn
Received: July 29, 2025
Revised: September 2, 2025
Accepted: October 17, 2025
Published online: December 27, 2025
Processing time: 148 Days and 18.2 Hours
Revised: September 2, 2025
Accepted: October 17, 2025
Published online: December 27, 2025
Processing time: 148 Days and 18.2 Hours
Core Tip
Core Tip: This study reveals that intestinal obstruction (IO) leads to gut-vascular barrier (GVB) damage, with PV1 expression positively correlating with infection, liver/kidney injury, and adverse outcomes. GVB impairment may contribute to IO pathogenesis, highlighting PV1 as a potential prognostic biomarker.