Risk factors of fever following endoscopic radiofrequency ablation for early esophageal squamous cell carcinoma and precancerous lesions

Table 1 General information

	No fever	Fever	Statistics	P value
Sex (n)				0.164
Male	7	16
Female	4	2
Age (years)	65.27 ± 6.94	69.44 ± 7.49	-1.495	0.146
Height (m)	1.66 ± 0.11	1.64 ± 0.60	0.721	0.483
Weight (kg)	68.73 ± 15.32	60.83 ± 5.74	1.640	0.127
BMI (kg/m2)	24.66 ± 3.53	22.78 ± 2.59	1.655	0.110
Smoke (n)
No	10	14		0.622
Yes	1	4
Drink (n)				0.622
No	9	16
Yes	2	2
Hypertension (n)				0.128
No	3	11
Yes	8	7
Diabetes (n)
No	10	14		0.622
Yes	1	4

BMI: Body mass index.

Table 2 Univariate analysis of fever after endoscopic radiofrequency ablation

	No fever	Fever	Statistics	P value
Ablation length (cm)	12.45 ± 4.57	16.10 ± 3.21	-2.496	0.019
Operate time (min)	57.00 ± 14.96	59.89 ± 16.97	-0.464	0.646
Postoperative fasting time (d)	2.91 ± 0.94	2.28 ± 0.67	2.109	0.044
Whether to use hormones after surgery (n)				0.646
No	8	15
Yes	3	3
Whether antibiotics should be used after surgery (n)				0.449
No	8	10
Yes	3	8
The pathology type (n)				0.719
Low-grade intraepithelial neoplasia	6	9
High-grade intraepithelial neoplasia	5	7
Early esophageal squamous cell carcinoma	0	2

Table 3 Multivariate logistic regression analysis of fever after endoscopic radiofrequency ablation

Variable	β	SE	Wald	P value	OR	95%CI
Ablation length (cm)	0.390	0.177	4.870	0.027	1.477	1.045-2.088
Postoperative fasting time (day)	-1.572	0.739	4.524	0.033	0.208	0.049-0.884

Table 4 The influence of postoperative fever on postoperative hospital stay and treatment cost

	No fever	Fever	t	P value
Total treatment costs (CNY)	28452.73 ± 5829.70	30505.24 ± 7158.48	-0.794	0.434
Postoperative length of stay (cm)	5.55 ± 2.11	7.29 ± 2.73	-1.798	0.084

One patient was transferred to surgery for further treatment, so it was not included in the calculation.

Table 5 Postoperative fever white blood cell count comparison

	Preoperative	Postoperative	t	P value
White blood cell count (× 109/L)	5.81 ± 1.82	11.24 ± 4.52	-5.61	0.000