Published online Nov 27, 2025. doi: 10.4240/wjgs.v17.i11.109628
Revised: August 19, 2025
Accepted: September 16, 2025
Published online: November 27, 2025
Processing time: 132 Days and 19 Hours
Recent studies have revealed that endoscopic minimally invasive treatment of early esophageal cancer and precancerous lesions is as effective as traditional surgery and offer considerable advantages, such as minimal invasiveness, en
To analyze factors affecting postoperative fever in patients with early esophageal squamous cell carcinoma and precancerous lesions who underwent endoscopic radiofrequency ablation (ERFA).
Clinical data of 29 patients with esophageal lesions admitted to The Affiliated Huai’an No. 1 People’s Hospital of Nanjing Medical University between March 2022 and June 2024 were retrospectively analyzed. All patients underwent ERFA and were divided into a fever group and a non-fever group based on whether they experienced fever after surgery. The general characteristics of both groups were analyzed, and univariate analysis of variance and multivariate logistic re
Among the 29 patients with esophageal lesions treated with ERFA, 11 did not experience fever, whereas 18 (62.07%) experienced it. Univariate analysis of variance showed that the ablation length and duration of postoperative fasting were significantly different between the fever and non-fever groups (P < 0.05), whereas the operation time, postoperative use of hormones, postoperative use of antibiotics, and pathological type were not significantly different between these groups (P > 0.05). Multivariate logistic regression indicated that the ablation length and duration of postoperative fasting were independent factors influencing the occurrence of post-ERFA fever.
The incidence of fever is high in patients with early esophageal lesions treated with ERFA, which is related to the ablation length and duration of postoperative fasting. The results can guide modifications in the treatment and nursing plans for patients with esophageal lesions to reduce the risk of postoperative fever.
Core Tip: With the continuous advancement of endoscopic therapeutic techniques, endoscopic treatment for early esophageal cancer and precancerous lesions has become an increasing trend in recent years. Radiofrequency ablation (RFA), a minimally invasive therapeutic technique, has emerged in recent years for the treatment of gastrointestinal lesions and is widely adopted in Western countries. Given the high incidence of esophageal squamous cell carcinoma in China, this study primarily aimed to observe the clinical efficacy of endoscopic RFA in the treatment of early esophageal squamous cell carcinoma and precancerous lesions and explore the factors influencing postoperative fever.