Quantitative evaluation for preoperative clinical stage of colorectal cancer using dynamic contrast-enhanced magnetic resonance imaging

Table 1 The values of volume transfer constant, rate constant, or extravascular extracellular volume fraction in the colorectal cancer and benign tumor group

Group	Case	Ktrans (minute-1)	Kep (minute-1)	Ve (%)
CRC	46	1.03 ± 0.28	2.31 ± 0.34	0.59 ± 0.11
Benign tumor	40	0.72 ± 0.24	2.02 ± 0.30	0.50 ± 0.06
t		5.469	4.165	4.610
P value		< 0.001	< 0.001	< 0.001

Ktrans: Volume transfer constant; Kep: Rate constant; Ve: Extravascular extracellular volume fraction; CRC: Colorectal cancer.

Table 2 The diagnostic performance of volume transfer constant, rate constant, and extravascular extracellular volume fraction alone or as a combined tool for colorectal cancer

Parameter	Cutoff value	AUC	SE	Sig	95%CI	Youden index	Specificity (%)	Sensitivity (%)
Ktrans (minute-1)	0.905 minute-1	0.814	0.045	0.000	0.725-0.903	0.496	80.00	69.60
Kep (minute-1)	2.225 minute-1	0.765	0.051	0.000	0.665-0.866	0.396	70.00	69.60
Ve (%)	0.585%	0.795	0.048	0.000	0.701-0.889	0.497	97.50	52.20
Combine	-	0.863	0.043	0.000	0.779-0.947	0.726	90.00	82.60

Ktrans: Volume transfer constant; Kep: Rate constant; Ve: Extravascular extracellular volume fraction; AUC: Area under the curve; SE: Standard error; Sig: Significance; CI: Confidence interval.

Table 3 Values of volume transfer constant, rate constant, and extravascular extracellular volume fraction in colorectal cancer patients with different T and N stages

Stage		Case	Ktrans (minute-1)	Kep (minute-1)	Ve (%)
T stage	T1-T2	27	0.87 ± 0.20	2.10 ± 0.29	0.53 ± 0.12
	T3-T4	19	1.24 ± 0.25	2.61 ± 0.37	0.67 ± 0.13
	t	-	5.570	5.239	3.765
	P value	-	< 0.001	< 0.001	0.001
N stage	N0	25	0.92 ± 0.18	2.05 ± 0.36	0.52 ± 0.11
	N1-N2	21	1.16 ± 0.22	2.63 ± 0.39	0.67 ± 0.14
	t	-	4.071	5.240	4.069
	P value	-	< 0.001	< 0.001	< 0.001

Ktrans: Volume transfer constant; Kep: Rate constant; Ve: Extravascular extracellular volume fraction.

Table 4 Spearman correlation analysis of volume transfer constant, rate constant, and extravascular extracellular volume fraction with T and N stages of colorectal cancer

Parameter	T stage		N stage
	r	P value	r	P value
Ktrans (minute-1)	0.528	0.002	0.519	0.002
Kep (minute-1)	0.503	0.004	0.602	0.001
Ve (%)	0.496	0.005	0.520	0.002

Ktrans: Volume transfer constant; Kep: Rate constant; Ve: Extravascular extracellular volume fraction.

Table 5 Preoperative evaluation of volume transfer constant, rate constant, and extravascular extracellular volume fraction for T stage of colorectal cancer

Parameter	Cutoff value	AUC	SE	Sig	95%CI	Youden index	Specificity (%)	Sensitivity (%)
Ktrans (minute-1)	0.935 minute-1	0.930	0.036	0.000	0.859-1.000	0.762	81.48	94.70
Kep (minute-1)	2.135 minute-1	0.828	0.062	0.000	0.707-0.950	0.546	70.37	84.20
Ve (%)	0.580%	0.872	0.051	0.000	0.772-0.973	0.620	77.78	84.20

AUC: Area under the curve; SE: Standard error; Sig: Significance; CI: Confidence interval; Ktrans: Volume transfer constant; Kep: Rate constant; Ve: Extravascular extracellular volume fraction.

Table 6 Preoperative evaluation of volume transfer constant, rate constant, and extravascular extracellular volume fraction for N stage of colorectal cancer

Parameter	Cutoff value	AUC	SE	Sig	95%CI	Youden index	Specificity (%)	Sensitivity (%)
Ktrans (minute-1)	0.935 minute-1	0.773	0.072	0.002	0.633-0.914	0.530	72.00	81.00
Kep (minute-1)	2.470 minute-1	0.927	0.042	0.000	0.826-1.000	0.770	96.00	81.00
Ve (%)	0.585%	0.649	0.081	0.085	0.489-0.808	0.171	60.00	57.10

AUC: Area under the curve; SE: Standard error; Sig: Significance; CI: Confidence interval; Ktrans: Volume transfer constant; Kep: Rate constant; Ve: Extravascular extracellular volume fraction.