Analysis of gut microbiota and serum I-FABP and PRDX1 levels in children with enterocolitis after congenital megacolon surgery

Figure 1 Box plot of gut microbiota α-diversity indices between Hirschsprung-associated enterocolitis and non-Hirschsprung-associated enterocolitis groups. A: Chaol index comparison; B: Shannon index comparison; C: Simpson index comparison. HAEC: Hirschsprung-associated enterocolitis.

Figure 2 Comparison of gut microbiota abundance at the phylum level between the Hirschsprung-associated enterocolitis and non-Hirschsprung-associated enterocolitis groups. A: Proteobacteria abundance; B: Actinobacteria abundance; C: Firmicutes abundance; D: Bacteroidetes abundance; E: Verrucomicrobia abundance; F: Tenericutes abundance. HAEC: Hirschsprung-associated enterocolitis.

Figure 3 Comparison of gut microbiota abundance at the genus level between the Hirschsprung-associated enterocolitis and non-Hirschsprung-associated enterocolitis groups. A: Bifidobacterium abundance; B: Enterobacter abundance; C: Shigella abundance; D: Streptococcus abundance; E: Bacteroides abundance; F: Lactobacillus abundance. HAEC: Hirschsprung-associated enterocolitis.

Figure 4 Correlation analysis results of intestinal flora and serum indicators. PRDX1: Peroxiredoxin 1; I-FABP: Intestinal fatty acid-binding protein; CRP: C-reactive protein; TNF-α: Tumor necrosis factor-alpha; IL-6: Interleukin-6; IL-8: Interleukin-8.

Figure 5 Risk nomogram prediction model of postoperative Hirschsprung-associated enterocolitis in children with Hirschsprung’s disease. PRDX1: Peroxiredoxin 1; FABP: Fatty acid-binding protein; CRP: C-reactive protein.

Figure 6 Calibration curve and decision curve analysis of the nomogram model. A: Calibration curve; B: Decision curve analysis.