Sun HL, Cui YT, Huo BL, Zheng XC, Kang WL. Analysis of gut microbiota and serum I-FABP and PRDX1 levels in children with enterocolitis after congenital megacolon surgery. World J Gastrointest Surg 2026; 18(4): 116578 [DOI: 10.4240/wjgs.v18.i4.116578]
Corresponding Author of This Article
Wei-Li Kang, Department of Pediatric, Hengshui People's Hospital, No. 180 Renmin East Road, Hengshui 053099, Hebei Province, China. kangweili666@163.com
Research Domain of This Article
Pediatrics
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Apr 27, 2026 (publication date) through Apr 24, 2026
Times Cited of This Article
Times Cited (0)
Journal Information of This Article
Publication Name
World Journal of Gastrointestinal Surgery
ISSN
1948-9366
Publisher of This Article
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Share the Article
Sun HL, Cui YT, Huo BL, Zheng XC, Kang WL. Analysis of gut microbiota and serum I-FABP and PRDX1 levels in children with enterocolitis after congenital megacolon surgery. World J Gastrointest Surg 2026; 18(4): 116578 [DOI: 10.4240/wjgs.v18.i4.116578]
World J Gastrointest Surg. Apr 27, 2026; 18(4): 116578 Published online Apr 27, 2026. doi: 10.4240/wjgs.v18.i4.116578
Analysis of gut microbiota and serum I-FABP and PRDX1 levels in children with enterocolitis after congenital megacolon surgery
Hua-Lin Sun, Yu-Tong Cui, Bing-Li Huo, Xiao-Cui Zheng, Wei-Li Kang
Hua-Lin Sun, Bing-Li Huo, Wei-Li Kang, Department of Pediatric, Hengshui People’s Hospital, Hengshui 053099, Hebei Province, China
Yu-Tong Cui, Department of Pediatric, Hebei Medical University, Shijiazhuang 050011, Hebei Province, China
Xiao-Cui Zheng, Department of Pediatric, Chengde Medical University, Chengde 067000, China
Co-first authors: Hua-Lin Sun and Yu-Tong Cui.
Author contributions: Sun HL and Cui YT were the guarantors and designed the study and they contribute equally to this study as co-first authors; Sun HL, Cui YT, Huo BL and Zheng XC participated in the acquisition, analysis, and interpretation of the data, and drafted the initial manuscript; Kang WL revised the article critically for important intellectual content.
Institutional review board statement: The study was reviewed and approved by the Ethics Committee of Hengshui People's Hospital (Approval No. AF/SC-08/02.0).
Informed consent statement: All study participants, or their legal guardians, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: There are no conflicts of interest to declare.
Data sharing statement: No additional data are available.
Corresponding author: Wei-Li Kang, Department of Pediatric, Hengshui People's Hospital, No. 180 Renmin East Road, Hengshui 053099, Hebei Province, China. kangweili666@163.com
Received: November 28, 2025 Revised: December 30, 2025 Accepted: February 9, 2026 Published online: April 27, 2026 Processing time: 146 Days and 22 Hours
Core Tip
Core Tip: This retrospective study examined the characteristics of, and correlations between, preoperative gut microbiota and serum intestinal fatty acid-binding protein (I-FABP) and peroxiredoxin 1 (PRDX1) levels in children who developed Hirschsprung-associated enterocolitis (HAEC) after Hirschsprung’s disease (HD) surgery, with the aim of informing risk assessment and preventive intervention strategies. Preliminary analyses indicated that children with postoperative HAEC exhibited decreased abundance of beneficial bacteria, increased abundances of pathogenic bacteria and elevated preoperative levels of C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interleukin-8 (IL-8), I-FABP and PRDX1. Preoperative levels of CRP, TNF-α, IL-6, IL-8, I-FABP and PRDX1 were significantly correlated with gut microbiota abundance, and the risk of HAEC after HD was strongly associated with preoperative gut microbiota structure and with I-FABP and PRDX1 levels.
