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World J Gastrointest Surg. Apr 27, 2026; 18(4): 117397
Published online Apr 27, 2026. doi: 10.4240/wjgs.v18.i4.117397
Published online Apr 27, 2026. doi: 10.4240/wjgs.v18.i4.117397
Helicobacter pylori positively associated with colorectal cancer and advanced, but not low-risk, adenomas: A retrospective study in China
Na Shan, Jun-Jie Hou, Chao-Qiong Jin, Qi Jin, Yue-Hua Qin, Wei-Wei Li, Department of Gastroenterology, Shaoxing People’s Hospital, The First Affiliated Hospital of Shaoxing University, Shaoxing 312000, Zhejiang Province, China
Author contributions: Shan N, Hou JJ, Jin CQ, Jin Q, Qin YH, and Li WW contributed to acquisition, analysis, or interpretation of data; Li WW contributed to concept, design, drafting of the manuscript and statistical analysis. All authors contributed to the article and approved the submitted version.
Supported by the Shaoxing City Health Science and Technology Plan Project Foundation of China, No. 2023SKY025.
Institutional review board statement: This investigation was approved by the Medical Ethics Committee of Shaoxing People’s Hospital (Approval No. IEC-K-AF-016-1.3).
Informed consent statement: The need for patient consent was waived due to the retrospective nature of the study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Corresponding author: Wei-Wei Li, Associate Chief Physician, Department of Gastroentero
Received: December 8, 2025
Revised: December 25, 2025
Accepted: February 5, 2026
Published online: April 27, 2026
Processing time: 139 Days and 16.2 Hours
Revised: December 25, 2025
Accepted: February 5, 2026
Published online: April 27, 2026
Processing time: 139 Days and 16.2 Hours
Core Tip
Core Tip: In the Chinese population, it remains unclear whether Helicobacter pylori (H. pylori) infection is involved in the early stages of colorectal carcinogenesis or is associated with the risk of colorectal polyps. We conducted a retrospective study based on 5986 gastroscopy and colonoscopy patients without a treatment history of H. pylori in Zhejiang Province (China). We found that H. pylori infection was a risk factor for both advanced adenomas and colorectal cancer in a similar clinical population of Chinese, but not non-adenomatous polyps or low-risk adenomas. Therefore, H. pylori-positive patients should undergo colonoscopy.