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World J Gastrointest Surg. Apr 27, 2026; 18(4): 115698
Published online Apr 27, 2026. doi: 10.4240/wjgs.v18.i4.115698
Published online Apr 27, 2026. doi: 10.4240/wjgs.v18.i4.115698
Loop ileostomy-induced reversible nonalcoholic fatty liver disease in a rectal cancer patient: A case report and review of literature
Yong-Kang Liang, Ju-He Zhang, Song Liang, Shen-Wei Wu, Xue-Yi Feng, Department of General Surgery, Lu’an Hospital of Anhui Medical University (Lu’an People’s Hospital of Anhui Province), Lu’an 237005, Anhui Province, China
Co-first authors: Yong-Kang Liang and Ju-He Zhang.
Co-corresponding authors: Shen-Wei Wu and Xue-Yi Feng.
Author contributions: Liang YK and Zhang JH contributed equally to manuscript writing and editing, and data collection; they made equal contributions; Liang S contributed to conceptualization and supervision; Feng XY and Wu SW contributed equally to revising the article and supervision; all authors have read and approved the final manuscript.
Supported by Bengbu Medical University Research Fund, No. 2024byzd288.
Informed consent statement: Written informed consent was obtained from the participant for both participation and publication of clinical data.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Xue-Yi Feng, MD, PhD, Department of General Surgery, Lu’an Hospital of Anhui Medical University (Lu’an People’s Hospital of Anhui Province), No. 21 West Wanxi Road, Lu’an 237005, Anhui Province, China. fxy514270277@126.com
Received: October 24, 2025
Revised: December 4, 2025
Accepted: February 12, 2026
Published online: April 27, 2026
Processing time: 183 Days and 0.8 Hours
Revised: December 4, 2025
Accepted: February 12, 2026
Published online: April 27, 2026
Processing time: 183 Days and 0.8 Hours
Core Tip
Core Tip: This case highlights a rare, reversible occurrence of nonalcoholic fatty liver disease following loop ileostomy in a rectal cancer patient. The temporal association between ileostomy, increased appetite, dyslipidemia, and fluctuations in glucagon-like peptide 1 and peptide YY(3-36) levels suggests a potential metabolic impact of ileostomy. These findings introduce a novel hypothesis linking gastrointestinal anatomical changes to hepatic lipid accumulation, warranting further mechanistic investigation.