Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastrointest Surg. Apr 27, 2026; 18(4): 115467
Published online Apr 27, 2026. doi: 10.4240/wjgs.v18.i4.115467
Published online Apr 27, 2026. doi: 10.4240/wjgs.v18.i4.115467
Microbiota-bile acid crosstalk and hepatic gluconeogenesis after intestinal resection: Revisiting the gut-liver axis for metabolic recovery
Gang Wang, Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China
Sheng-Jie Pan, Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China
Co-corresponding authors: Gang Wang and Sheng-Jie Pan.
Author contributions: Wang G and Pan SJ contributed equally to this manuscript and are co-corresponding authors. Wang G contributed to conceptualization, interpretation of mechanistic implications, and critical revision of the manuscript; Pan SJ contributed to literature analysis, drafting of the manuscript, and integration of immunometabolic concepts; Wang G and Pan SJ contributed to data interpretation, responsibility for the accuracy and integrity of the work, approval of the final version, and agreement to be accountable for all aspects of the work.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Gang Wang, PhD, MD, Professor, Department of General Surgery, The First Affiliated Hospital of Soochow University, No. 899 Pinghai Road, Suzhou 215006, Jiangsu Province, China. 286651551@qq.com
Received: October 20, 2025
Revised: November 25, 2025
Accepted: January 4, 2026
Published online: April 27, 2026
Processing time: 189 Days and 4.8 Hours
Revised: November 25, 2025
Accepted: January 4, 2026
Published online: April 27, 2026
Processing time: 189 Days and 4.8 Hours
Core Tip
Core Tip: Intestinal resection reshapes systemic metabolism through coordinated microbiota-bile acid-hepatic signaling. Xu et al identified a 7-ketolithocholic acid-mediated farnesoid X receptor pathway linking microbial metabolism to suppression of hepatic gluconeogenesis. This editorial integrates these findings with broader immunometabolic and circadian mechanisms, emphasizing the role of bile acid signaling in postoperative metabolic adaptation. These insights highlight potential strategies for microbiota-targeted and receptor-based interventions to enhance metabolic recovery after surgery.