Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastrointest Surg. Mar 27, 2026; 18(3): 115320
Published online Mar 27, 2026. doi: 10.4240/wjgs.v18.i3.115320
Published online Mar 27, 2026. doi: 10.4240/wjgs.v18.i3.115320
MUC16 indicates poor prognosis in coexistent pancreatic ductal adenocarcinoma and serous cystadenoma: A case report and review of literature
Ya-Tong Li, Hua-Dan Xue, Zheng-Yu Jin, Zhi-Wei Wang, Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
Yu-Pei Zhang, Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
Qing-Di Fang, School of Medicine, Tsinghua University, Beijing 100084, China
Huan-Wen Wu, Yu Xiao, Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
Wen-Ming Wu, Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
Co-first authors: Ya-Tong Li and Yu-Pei Zhang.
Author contributions: Li YT and Zhang YP drafted the manuscript as co-first authors; Li YT, Zhang YP, and Fang QD finished data analysis; Li YT and Wang ZW accomplished the study conception and design, and critically revised manuscript; Wu HW, Xiao Y, Wu WM, Xue HD, and Jin ZY finished data acquisition and documentation; Wang ZW was responsible for proofreading and author communication; all the authors approved the final manuscript.
Supported by National Natural Science Foundation of China, No. 81903150 and No. 22232006; National Key Research and Development Program of China, No. 2023YFA0915304; and Beijing Natural Science Foundation Program, No. 7194305.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Zhi-Wei Wang, MD, Full Professor, Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Wangfujing Avenue, Beijing 100730, China.
Received: October 16, 2025
Revised: November 7, 2025
Accepted: January 9, 2026
Published online: March 27, 2026
Processing time: 164 Days and 8.7 Hours
Revised: November 7, 2025
Accepted: January 9, 2026
Published online: March 27, 2026
Processing time: 164 Days and 8.7 Hours
Core Tip
Core Tip: The coexistent pancreatic ductal adenocarcinoma and serous cystadenoma occur rarely, accompanied by challenges in diagnosis. MUC16 is associated with poor prognosis in coexistent pancreatic ductal adenocarcinoma and serous cystadenoma. Enhancing the precision and accuracy of preoperative imaging diagnoses is of paramount importance in the differential diagnosis of coexistent pancreatic lesions.