©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
World J Gastrointest Surg. Feb 27, 2026; 18(2): 115622
Published online Feb 27, 2026. doi: 10.4240/wjgs.v18.i2.115622
Published online Feb 27, 2026. doi: 10.4240/wjgs.v18.i2.115622
Prognostic value of primary tumor site in surgery for colorectal liver metastases
Felix Pius Omullo, Department of Medical Services, Equity Afya, Lodwar 399-30500, Turkana, Kenya
Author contributions: Omullo FP was solely responsible for the conceptualization, drafting, critical revision, and final approval of this manuscript.
Conflict-of-interest statement: The author reports no relevant conflicts of interest for this article.
Corresponding author: Felix Pius Omullo, MD, Senior Researcher, Department of Medical Services, Equity Afya, Kanaamkemer, Lodwar 399-30500, Turkana, Kenya.
Received: October 21, 2025
Revised: October 24, 2025
Accepted: December 17, 2025
Published online: February 27, 2026
Processing time: 128 Days and 12.7 Hours
Revised: October 24, 2025
Accepted: December 17, 2025
Published online: February 27, 2026
Processing time: 128 Days and 12.7 Hours
Core Tip
Core Tip: Primary tumor location is a master prognostic regulator in colorectal liver metastases. Right-sided origin defines an aggressive biologic phenotype, marked by chemoresistance, hypercoagulability, and systemic decline, culminating in a more than 50% 1-year recurrence rate and a 13-month survival deficit. These findings mandate abandoning a one-size-fits-all management approach. Therefore, the immediate implementation of the following site-specific protocols remains paramount: Preoperative risk stratification, therapeutic intensification, and personalized intensive surveillance for right-sided cases.