©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
World J Gastrointest Surg. Feb 27, 2026; 18(2): 113698
Published online Feb 27, 2026. doi: 10.4240/wjgs.v18.i2.113698
Published online Feb 27, 2026. doi: 10.4240/wjgs.v18.i2.113698
Safety and efficacy of endoscopic papillectomy for duodenal papillary adenomas: A single-center retrospective study
Lei Xu, Si-Jia Chen, Pin Wang, Xiao-Ping Zou, Lei Wang, Yi Wang, Department of Gastro
Liang Mao, Department of Pancreatic Surgery, Drum Tower Hospital, Nanjing University School of Medicine, Nanjing 210008, Jiangsu Province, China
Co-first authors: Lei Xu and Si-Jia Chen.
Author contributions: Xu L and Chen SJ contributed equally to this work as co-first authors; Wang Y, Wang L, and Zou XP designed the study and drafted the manuscript; Xu L, Chen SJ, Wang P, and Mao L collected the data; all authors reviewed and approved the final manuscript.
Supported by Nanjing Drum Tower Hospital Clinical Research Special Funds, No. 2022-LCYJ-PY-34.
Institutional review board statement: The study was reviewed and approved by the Ethics Committee of Drum Tower Hospital, Nanjing University School of Medicine (Approval No. 2021-401-02).
Informed consent statement: All study participants, or their legal guardians, provided informed written consent before study enrollment.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Data sharing statement: The data used and analyzed during the study are available from the corresponding author upon reasonable request. All participants provided informed consent for data sharing.
Corresponding author: Yi Wang, PhD, Department of Gastroenterology, Drum Tower Hospital, Nanjing University School of Medicine, No. 321 Zhongshan Road, Nanjing 210008, Jiangsu Province, China. wangyired@foxmail.com
Received: September 1, 2025
Revised: October 6, 2025
Accepted: December 15, 2025
Published online: February 27, 2026
Processing time: 178 Days and 15.5 Hours
Revised: October 6, 2025
Accepted: December 15, 2025
Published online: February 27, 2026
Processing time: 178 Days and 15.5 Hours
Core Tip
Core Tip: Endoscopic papillectomy (EP) is a minimally invasive, effective, and safe treatment for duodenal papillary neoplasms, offering comparable recurrence rates and superior long-term survival benefits to pancreaticoduodenectomy (PD). While PD has a low recurrence rate, its high postoperative complications limit its use. This study found similar recurrence rates between EP and PD, with fewer complications in the endoscopic group. EP is a viable alternative to PD for treating duodenal papillary neoplasms.