Xu L, Chen SJ, Wang P, Mao L, Zou XP, Wang L, Wang Y. Safety and efficacy of endoscopic papillectomy for duodenal papillary adenomas: A single-center retrospective study. World J Gastrointest Surg 2026; 18(2): 113698 [DOI: 10.4240/wjgs.v18.i2.113698]
Corresponding Author of This Article
Yi Wang, PhD, Department of Gastroenterology, Drum Tower Hospital, Nanjing University School of Medicine, No. 321 Zhongshan Road, Nanjing 210008, Jiangsu Province, China. wangyired@foxmail.com
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Gastroenterology & Hepatology
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Retrospective Study
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Feb 27, 2026 (publication date) through Feb 26, 2026
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World Journal of Gastrointestinal Surgery
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1948-9366
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Xu L, Chen SJ, Wang P, Mao L, Zou XP, Wang L, Wang Y. Safety and efficacy of endoscopic papillectomy for duodenal papillary adenomas: A single-center retrospective study. World J Gastrointest Surg 2026; 18(2): 113698 [DOI: 10.4240/wjgs.v18.i2.113698]
World J Gastrointest Surg. Feb 27, 2026; 18(2): 113698 Published online Feb 27, 2026. doi: 10.4240/wjgs.v18.i2.113698
Safety and efficacy of endoscopic papillectomy for duodenal papillary adenomas: A single-center retrospective study
Lei Xu, Si-Jia Chen, Pin Wang, Liang Mao, Xiao-Ping Zou, Lei Wang, Yi Wang
Lei Xu, Si-Jia Chen, Pin Wang, Xiao-Ping Zou, Lei Wang, Yi Wang, Department of Gastroenterology, Drum Tower Hospital, Nanjing University School of Medicine, Nanjing 210008, Jiangsu Province, China
Liang Mao, Department of Pancreatic Surgery, Drum Tower Hospital, Nanjing University School of Medicine, Nanjing 210008, Jiangsu Province, China
Co-first authors: Lei Xu and Si-Jia Chen.
Author contributions: Xu L and Chen SJ contributed equally to this work as co-first authors; Wang Y, Wang L, and Zou XP designed the study and drafted the manuscript; Xu L, Chen SJ, Wang P, and Mao L collected the data; all authors reviewed and approved the final manuscript.
Supported by Nanjing Drum Tower Hospital Clinical Research Special Funds, No. 2022-LCYJ-PY-34.
Institutional review board statement: The study was reviewed and approved by the Ethics Committee of Drum Tower Hospital, Nanjing University School of Medicine (Approval No. 2021-401-02).
Informed consent statement: All study participants, or their legal guardians, provided informed written consent before study enrollment.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Data sharing statement: The data used and analyzed during the study are available from the corresponding author upon reasonable request. All participants provided informed consent for data sharing.
Corresponding author: Yi Wang, PhD, Department of Gastroenterology, Drum Tower Hospital, Nanjing University School of Medicine, No. 321 Zhongshan Road, Nanjing 210008, Jiangsu Province, China. wangyired@foxmail.com
Received: September 1, 2025 Revised: October 6, 2025 Accepted: December 15, 2025 Published online: February 27, 2026 Processing time: 178 Days and 15.5 Hours
Abstract
BACKGROUND
Pancreaticoduodenectomy (PD) is currently the preferred surgical procedure to remove duodenal papillary adenoma. It offers a low recurrence rate, but a high rate of postoperative complications.
AIM
To determine the efficacy and safety of endoscopic papillectomy (EP) for duodenal papillary adenoma.
METHODS
This retrospective case-control study included 102 patients who received treatment at Nanjing Drum Tower Hospital between January 2010 and December 2024. Clinicopathological features, adverse events, and outcomes were compared between the two groups.
RESULTS
After propensity score matching for sex, year, and tumor size, 37 patients each were assigned to the PD and EP groups. All patients underwent successful removal of the diseased tissues. The pathological analysis revealed no significant differences between the two groups (P > 0.05). The PD group exhibited a significantly higher incidence of pancreatic fistula and intra-abdominal infection after surgery. Two patients in the PD group died from surgery-related complications, whereas no mortality was observed in the EP group (P = 0.152).
CONCLUSION
EP may be effective and safe for the removal of duodenal papillary adenoma in a minimally invasive manner, and can offer superior long-term survival compared with conventional PD.
Core Tip: Endoscopic papillectomy (EP) is a minimally invasive, effective, and safe treatment for duodenal papillary neoplasms, offering comparable recurrence rates and superior long-term survival benefits to pancreaticoduodenectomy (PD). While PD has a low recurrence rate, its high postoperative complications limit its use. This study found similar recurrence rates between EP and PD, with fewer complications in the endoscopic group. EP is a viable alternative to PD for treating duodenal papillary neoplasms.
