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World J Gastrointest Surg. Feb 27, 2026; 18(2): 113476
Published online Feb 27, 2026. doi: 10.4240/wjgs.v18.i2.113476
Published online Feb 27, 2026. doi: 10.4240/wjgs.v18.i2.113476
Association between type 2 diabetes mellitus and colorectal adenoma: A retrospective study with insights into Wnt/β-Catenin/TCF7L2 pathway activation
Shu-Yan Gui, Ruo-Xi Tang, Xing Huang, Guo-Qiang Yang, Jing Yang, Department of Endo
Author contributions: Gui SY designed the research and wrote the original manuscript; Gui SY, Tang RX, Huang X and Yang GQ contributed to conceiving the research and analyzing data; Yang J conducted the analysis and provided guidance for the research. All authors reviewed and approved the final manuscript.
Supported by the Outstanding Team Fund of the Nanshan District Health System - Shenzhen City, No. NSZD2025004; and the Major Science and Technology Plan Project of Nanshan District - Shenzhen City, No. NSZD2025016 and No. NSZD2024017.
Institutional review board statement: This study was a retrospective analysis, the data were de-identified, and it was collected retrospectively, so no Institutional Review Board certification was required.
Informed consent statement: Data was de-identified and retrospectively collected, and therefore informed consent was not required from each patient.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Corresponding author: Jing Yang, PhD, Chief Physician, Department of Endocrinology, Shenzhen Nanshan People’s Hospital, Affiliated Nanshan Hospital of Shenzhen University, No. 89 Taoyuan Road, Nanshan District, Shenzhen 518052, Guangdong Province, China.
Received: October 14, 2025
Revised: November 17, 2025
Accepted: December 22, 2025
Published online: February 27, 2026
Processing time: 134 Days and 22 Hours
Revised: November 17, 2025
Accepted: December 22, 2025
Published online: February 27, 2026
Processing time: 134 Days and 22 Hours
Core Tip
Core Tip: This small-scale retrospective cohort study confirmed that type 2 diabetes mellitus is a significant independent risk factor for colorectal adenomas. The results of this study indicate that Wnt/β-catenin/transcription factor 7 like 2 pathway activation is considered a common molecular pathological basis in the association of type 2 diabetes mellitus with colorectal adenoma occurrence and development. The results of this study support the inclusion of colonoscopy screening in the routine clinical management pathway for patients with type 2 diabetes mellitus.