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World J Gastrointest Surg. Feb 27, 2026; 18(2): 112924
Published online Feb 27, 2026. doi: 10.4240/wjgs.v18.i2.112924
Published online Feb 27, 2026. doi: 10.4240/wjgs.v18.i2.112924
Post-chemotherapy C-reactive protein/albumin ratio predicts prognosis in stage II-III colorectal cancer
Fei-Fei Kong, Department of Oncology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221000, Jiangsu Province, China
Xuan Geng, Ru-Ming Liu, Wen-Tao Zhang, Bin Quan, Yong Zhong, You-Long Zhu, Department of Gastrointestinal Surgery, Xuzhou Central Hospital, Xuzhou 221000, Jiangsu Province, China
Co-corresponding authors: Yong Zhong and You-Long Zhu.
Author contributions: Kong FF designed the research, wrote the first manuscript, conducted the analysis, and provided guidance for the research; Kong FF, Geng X, Liu RM, Zhang WT, Quan B, Zhong Y, and Zhu YL contributed to conceiving the research and analyzing data; Zhong Y and Zhu YL made equal contributions as co-corresponding authors; all authors reviewed and approved the final manuscript.
Supported by The Affiliated Hospital of Xuzhou Medical University, No. 2023ZL08.
Institutional review board statement: The study was approved by the Institutional Review Board of The Affiliated Hospital of Xuzhou Medical University, No. XYFY2025-KL347-01.
Informed consent statement: Data was de-identified and retrospectively collected, and therefore informed consent was not required from each patient.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Corresponding author: You-Long Zhu, MD, Department of Gastrointestinal Surgery, Xuzhou Central Hospital, No. 199 Jiefang South Road, Xuzhou 221000, Jiangsu Province, China.
Received: September 16, 2025
Revised: November 4, 2025
Accepted: December 22, 2025
Published online: February 27, 2026
Processing time: 163 Days and 1.5 Hours
Revised: November 4, 2025
Accepted: December 22, 2025
Published online: February 27, 2026
Processing time: 163 Days and 1.5 Hours
Core Tip
Core Tip: In this study, we evaluated inflammation-related prognostic markers in patients with colorectal cancer. The results indicated a strong connection between C-reactive protein/albumin ratio values and adverse prognoses. Moreover, the longitudinal changes of inflammation-related prognostic markers had a significant impact on the prognosis of these patients following adjuvant chemotherapy. Therefore, assessing hematological markers is instrumental in evaluating disease progression and prognosis in patients with colorectal cancer.