Wu CM, Zhu WJ, Chen X, Liu M, Feng Y, Wang M. Risk factors for enteral nutrition intolerance and its impact on prognosis in patients with severe acute pancreatitis. World J Gastrointest Surg 2026; 18(1): 112334 [PMID: 41695844 DOI: 10.4240/wjgs.v18.i1.112334]
Corresponding Author of This Article
Mei Wang, MD, Department of Emergency Medicine, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Shushan District, Hefei 230022, Anhui Province, China. mei_wang7065@sina.com
Research Domain of This Article
Gastroenterology & Hepatology
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Retrospective Study
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Jan 27, 2026 (publication date) through Feb 19, 2026
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Publication Name
World Journal of Gastrointestinal Surgery
ISSN
1948-9366
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Wu CM, Zhu WJ, Chen X, Liu M, Feng Y, Wang M. Risk factors for enteral nutrition intolerance and its impact on prognosis in patients with severe acute pancreatitis. World J Gastrointest Surg 2026; 18(1): 112334 [PMID: 41695844 DOI: 10.4240/wjgs.v18.i1.112334]
World J Gastrointest Surg. Jan 27, 2026; 18(1): 112334 Published online Jan 27, 2026. doi: 10.4240/wjgs.v18.i1.112334
Risk factors for enteral nutrition intolerance and its impact on prognosis in patients with severe acute pancreatitis
Chang-Mei Wu, Wen-Jun Zhu, Xi Chen, Min Liu, Yuan Feng, Mei Wang
Chang-Mei Wu, Wen-Jun Zhu, Xi Chen, Min Liu, Yuan Feng, Mei Wang, Department of Emergency Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China
Co-first authors: Chang-Mei Wu and Wen-Jun Zhu.
Author contributions: Wu CM and Zhu WJ did conceptualization, data curation, investigation, and writing the original draft, they contributed equally to this article, they are the co-first authors of this manuscript; Wu CM, Zhu WJ, and Chen X did formal analysis; Chen X, Liu M, and Feng Y did data collection; Liu M did investigation and software; Chen X and Feng Y did visualization; Wu CM, Zhu WJ, Feng Y, and Wang M did methodology; Wang M did conceptualization, project administration, supervision, writing review and editing, and funding acquisition; and all the authors have read and approved the final manuscript.
Institutional review board statement: This study was approved by the Medical Ethics Committee of The First Affiliated Hospital of Anhui Medical University, approval No. PJ2024-05-90.
Informed consent statement: All patient information was anonymized and de-identified prior to analysis. The requirement for signed informed consent was waived by the institutional review board due to the retrospective nature of the study and minimal risk to participants.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: De-identified data and analysis code used in this study are available from the corresponding author upon reasonable request and with appropriate institutional approvals.
Corresponding author: Mei Wang, MD, Department of Emergency Medicine, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Shushan District, Hefei 230022, Anhui Province, China. mei_wang7065@sina.com
Received: August 15, 2025 Revised: September 24, 2025 Accepted: December 1, 2025 Published online: January 27, 2026 Processing time: 159 Days and 1.9 Hours
Core Tip
Core Tip: The incidence, risk factors, and prognostic significance of enteral nutrition (EN) intolerance in patients with severe acute pancreatitis were examined in this retrospective cohort study. The rate of EN intolerance among 195 patients was 39.0%. Multivariate analysis revealed that the Acute Physiology and Chronic Health Evaluation II score, serum albumin concentration, and intra-abdominal pressure were independent predictors. Patients with EN intolerance had significantly greater 28-day mortality. In addition to offering evidence for the optimization of EN therapy in critical care settings, these findings emphasize the significance of early risk assessment and customized nutritional measures to enhance outcomes for severe acute pancreatitis patients.
