Liu N, Liu J, Wang YL, Zhu L, Zhu CW. Knockdown of 5-methylcytosine RNA methyltransferase NOP2/sun RNA methyltransferase 5 in hepatocellular carcinoma cells affects their biological functions. World J Gastrointest Surg 2026; 18(1): 112243 [DOI: 10.4240/wjgs.v18.i1.112243]
Corresponding Author of This Article
Chuan-Wu Zhu, Chief Physician, Department of Infectious Diseases, The Affiliated Infectious Diseases Hospital, Suzhou Medical College of Soochow University, No. 10 Guangqian Road, Xiangcheng District, Suzhou 215131, Jiangsu Province, China. zhuchw@126.com
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Infectious Diseases
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Basic Study
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Jan 27, 2026 (publication date) through Jan 28, 2026
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Publication Name
World Journal of Gastrointestinal Surgery
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1948-9366
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Liu N, Liu J, Wang YL, Zhu L, Zhu CW. Knockdown of 5-methylcytosine RNA methyltransferase NOP2/sun RNA methyltransferase 5 in hepatocellular carcinoma cells affects their biological functions. World J Gastrointest Surg 2026; 18(1): 112243 [DOI: 10.4240/wjgs.v18.i1.112243]
World J Gastrointest Surg. Jan 27, 2026; 18(1): 112243 Published online Jan 27, 2026. doi: 10.4240/wjgs.v18.i1.112243
Knockdown of 5-methylcytosine RNA methyltransferase NOP2/sun RNA methyltransferase 5 in hepatocellular carcinoma cells affects their biological functions
Na Liu, Jin Liu, Yin-Ling Wang, Li Zhu, Chuan-Wu Zhu
Na Liu, Chuan-Wu Zhu, Department of Infectious Diseases, The Second Affiliated Hospital of Soochow University, Suzhou 215004, Jiangsu Province, China
Na Liu, Department of Infectious Diseases and Liver Diseases, The Second Hospital of Nanjing, Nanjing 210003, Jiangsu Province, China
Jin Liu, Yin-Ling Wang, Li Zhu, Chuan-Wu Zhu, Department of Infectious Diseases, The Affiliated Infectious Diseases Hospital, Suzhou Medical College of Soochow University, Suzhou 215131, Jiangsu Province, China
Jin Liu, Chuan-Wu Zhu, Department of Hepatology, The Fifth People's Hospital of Suzhou, Suzhou 215131, Jiangsu Province, China
Author contributions: Liu N drafted the initial manuscript, reviewed and refined the final version of the manuscript; Liu N, Liu J and Wang YL handled data collection; Liu N and Zhu L carried out the data analysis; Liu N and Zhu CW conducted the experiments; all authors approved the final version of the article.
Supported by National Natural Science Foundation of China, No. 82172252; and Suzhou Major Disease Multicenter Clinical Research Project, No. DZXYJ202310.
Conflict-of-interest statement: There is no conflict of interest.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chuan-Wu Zhu, Chief Physician, Department of Infectious Diseases, The Affiliated Infectious Diseases Hospital, Suzhou Medical College of Soochow University, No. 10 Guangqian Road, Xiangcheng District, Suzhou 215131, Jiangsu Province, China. zhuchw@126.com
Received: September 2, 2025 Revised: October 16, 2025 Accepted: November 27, 2025 Published online: January 27, 2026 Processing time: 141 Days and 1.2 Hours
Core Tip
Core Tip: Epigenetic modifications are dynamic, reversible, and heritable chemical changes to biomolecules that occur without altering the sequence of nuclear DNA. Among these, the RNA modification 5-methylcytosine has garnered increasing attention. However, the roles of RNA modification 5-methylcytosine modifications and their modifying enzymes in gene regulation and chromatin organization remain largely unclear. While previous studies have reported the involvement of NOP2/sun RNA methyltransferase 5 in human cancers, its comprehensive role in hepatocellular carcinoma remains unexplored. Therefore, this study evaluates the effects of NOP2/sun RNA methyltransferase 5 on hepatocellular carcinoma cell growth, migration, and invasion at the cellular level.
