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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Sep 27, 2025; 17(9): 110577
Published online Sep 27, 2025. doi: 10.4240/wjgs.v17.i9.110577
Published online Sep 27, 2025. doi: 10.4240/wjgs.v17.i9.110577
Hypertension and tachycardia induced by irreversible electroporation in pancreatic cancer: An analysis based on clinical data
Hong-Mei Li, Yan-Li Xing, Li-Zhi Niu, Department of Oncology, Guangzhou Fuda Cancer Hospital, Guangzhou 510665, Guangdong Province, China
Zi-Qing Chen, Shi-Xiong Duan, Department of Radiology, Guangzhou Fuda Cancer Hospital, Guangzhou 510665, Guangdong Province, China
Yang-Yang Ma, Central Laboratory, Guangzhou Fuda Cancer Hospital, Guangzhou 510665, Guangdong Province, China
Co-corresponding authors: Yang-Yang Ma and Li-Zhi Niu.
Author contributions: Li HM wrote the paper; Xing YL performed the study selection; Chen ZQ and Duan SX collected the data; Niu LZ and Ma YY designed the project, edited the manuscript, and made equal contributions as co-corresponding authors; all authors reviewed the final manuscript.
Supported by International Science Foundation of Guangzhou Fuda Cancer Hospital, No. Y2022-MS-02.
Institutional review board statement: This study was approved by the Ethic Committee of Fuda Cancer Hospital, No. FDCT-L-QX-2018-01.
Informed consent statement: Written informed consent was obtained from the individual(s) for the publication of any potentially identifiable images or data included in this article.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: All data are available upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Li-Zhi Niu, PhD, Chief Physician, Professor, Department of Oncology, Guangzhou Fuda Cancer Hospital, No. 2 Tangde West Road, Tianhe District, Guangzhou 510665, Guangdong Province, China. niuboshi@fudahospital.com
Received: June 11, 2025
Revised: July 3, 2025
Accepted: August 1, 2025
Published online: September 27, 2025
Processing time: 107 Days and 5.4 Hours
Revised: July 3, 2025
Accepted: August 1, 2025
Published online: September 27, 2025
Processing time: 107 Days and 5.4 Hours
Core Tip
Core Tip: This study highlights the incidence of intraoperative hypertension and tachycardia during irreversible electroporation for unresectable tumors, significantly correlated with electrode proximity to the abdominal aorta and adrenal glands. Notably, hypertension was observed in 56.4% of patients when electrodes were less than 2.0 cm from the aorta, while 14.1% experienced tachycardia with electrodes nearer than 1.3 cm to the adrenal glands. Preemptive administration of nicardipine and esmolol effectively mitigates these cardiovascular responses, suggesting essential preoperative management for enhancing patient safety during irreversible electroporation.