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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Sep 27, 2025; 17(9): 108715
Published online Sep 27, 2025. doi: 10.4240/wjgs.v17.i9.108715
Published online Sep 27, 2025. doi: 10.4240/wjgs.v17.i9.108715
Effect of comorbid gastroesophageal reflux disease on laryngopharyngeal reflux disease: Clinical characteristics and risk factors
Dan-Dan Xu, Department of Otolaryngology, Tiantai People's Hospital of Zhejiang Province, Taizhou 317200, Zhejiang Province, China
Author contributions: Xu DD designed the study and were involved in the data acquisition, writing of this article, and the analysis of the manuscript, read and approved the final version of the manuscript to be published.
Institutional review board statement: This study was approved by the Ethic Committee of Tiantai People's Hospital of Zhejiang Province.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: The author who has taken part in this study have nothing to disclose.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dan-Dan Xu, MM, Attending Physician, Department of Otolaryngology, Tiantai People's Hospital of Zhejiang Province, No. 1 Kangning Middle Road, Shifeng Sub
Received: May 30, 2025
Revised: June 25, 2025
Accepted: August 1, 2025
Published online: September 27, 2025
Processing time: 117 Days and 4 Hours
Revised: June 25, 2025
Accepted: August 1, 2025
Published online: September 27, 2025
Processing time: 117 Days and 4 Hours
Core Tip
Core Tip: This study enrolled 150 patients with laryngopharyngeal reflux disease (LPRD) and stratified them by gastroesophageal reflux disease (GERD) status (GERD group, n = 74; non-GERD group, n = 76) to assess the influence of GERD comorbidity on clinical manifestations while identifying possible risk determinants. GERD comorbidity significantly worsened symptoms in patients with LPRD, increased in flux event episodes, and aggravated flux severity. The independent risk factors included advanced age, female sex, smoking, and alcohol consumption.