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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Sep 27, 2025; 17(9): 107966
Published online Sep 27, 2025. doi: 10.4240/wjgs.v17.i9.107966
Published online Sep 27, 2025. doi: 10.4240/wjgs.v17.i9.107966
Survival benefit of primary tumor resection in pancreatic neuroendocrine tumors with unresectable liver metastases: A meta-analysis
Jie Gong, Ze-Hua Lei, Department of Hepatopancreatobiliary Surgery, The People’s Hospital of Leshan, Leshan 614000, Sichuan Province, China
Ben-Jian Gao, Department of General Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan Province, China
Co-first authors: Jie Gong and Ben-Jian Gao.
Author contributions: Gong J and Gao BJ contributed equally to this work as co-first authors; Gong J conducted the literature search, performed data extraction and statistical analysis, and drafted the manuscript; Gao BJ contributed to study design, data interpretation, and critical revision of the manuscript; Lei ZH conceived and supervised the study, provided clinical expertise, and finalized the manuscript. All authors read and approved the final version of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ze-Hua Lei, MD, Professor, Department of Hepatopancreatobiliary Surgery, The People’s Hospital of Leshan, No. 238 Baita Street, Leshan 614000, Sichuan Province, China. leitsehua@126.com
Received: April 2, 2025
Revised: June 25, 2025
Accepted: July 31, 2025
Published online: September 27, 2025
Processing time: 176 Days and 2.5 Hours
Revised: June 25, 2025
Accepted: July 31, 2025
Published online: September 27, 2025
Processing time: 176 Days and 2.5 Hours
Core Tip
Core Tip: This study comprehensively evaluates the impact of primary tumor resection (PTR) on survival in patients with pancreatic neuroendocrine tumors and unresectable liver metastases. Our meta-analysis, involving 16 studies and 8761 patients, demonstrates that PTR significantly improves overall survival. Analysis of the Surveillance, Epidemiology, and End Results database further supports these findings, showing consistent survival benefits across different tumor differentiation levels. However, PTR’s effect on tumor grading remains unclear, highlighting the need for further large-scale prospective studies to refine surgical approaches for this patient population.