Retrospective Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Jul 27, 2025; 17(7): 106901
Published online Jul 27, 2025. doi: 10.4240/wjgs.v17.i7.106901
Etomidate-propofol combination in painless gastrointestinal endoscopy for elderly patients: A comparative study
Ying-Yan Zhang
Ying-Yan Zhang, Department of Anesthesiology, People’s Hospital of Wuhan Economic and Technological Development Zone (Hannan District), Wuhan 430090, Hubei Province, China
Author contributions: Zhang YY designed the research and wrote the first manuscript; Zhang YY contributed to conceiving the research and analyzing data; Zhang YY conducted the analysis and provided guidance for the research.
Institutional review board statement: This study was approved by the Ethic Committee of People’s Hospital of Wuhan Economic and Technological Development Zone (Hannan District), on October 15, 2024.
Informed consent statement: Data was de-identified and retrospectively collected, and therefore informed consent was not required from each patient.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The datasets used and analyzed during the current study are available from the corresponding author on reasonable request at zyy19830515@163.com.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ying-Yan Zhang, Department of Anesthesiology, People’s Hospital of Wuhan Economic and Technological Development Zone (Hannan District), No. 275 Xingcheng Avenue, Wuhan 430090, Hubei Province, China. zyy19830515@163.com
Received: March 12, 2025
Revised: April 14, 2025
Accepted: May 28, 2025
Published online: July 27, 2025
Processing time: 133 Days and 3.6 Hours
Core Tip

Core Tip: The choice of anesthesia plays a pivotal role in ensuring both safety and efficacy during painless gastroscopy. This study enrolled 103 elderly patients scheduled for painless gastrointestinal endoscopy and systematically compared propofol monotherapy with a combined etomidate-propofol regimen. Comprehensive evaluations of anesthesia quality, patient compliance, hemodynamic stability, adverse events, and sedation-analgesia efficacy demonstrated that the etomidate-propofol combination provides distinct clinical advantages for such patients. These results support its adoption as a preferred anesthetic strategy for elderly patients undergoing painless gastrointestinal endoscopy.