Case Report
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Jul 27, 2025; 17(7): 104985
Published online Jul 27, 2025. doi: 10.4240/wjgs.v17.i7.104985
Multiple jejunal diverticulosis, from an anatomical and histological view: A case report
Patricia Schmidt, Alexander Perniss, Christina Nassenstein, Hanno Keller, Klaus Deckmann
Patricia Schmidt, Alexander Perniss, Christina Nassenstein, Klaus Deckmann, Institute for Anatomy and Cell Biology, Justus-Liebig-University Giessen, Giessen 35392, Hesse, Germany
Patricia Schmidt, Leibniz Institute on Aging, Fritz Lipmann Institute, Jena 07745, Thuringia, Germany
Alexander Perniss, Division of Allergy and Clinical Immunology, Brigham and Women's Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02115, United States
Hanno Keller, Laboratory of Experimental Surgery, Department of General and Thoracic Surgery, Justus-Liebig-University Giessen, Giessen 35392, Hesse, Germany
Co-first authors: Patricia Schmidt and Alexander Perniss.
Author contributions: Schmidt P and Perniss A contributed equally to this study as co-first authors; Deckmann K, Schmidt P, Keller H, and Perniss A performed the experiments, prepared the necessary materials, and recorded the data photographically; Deckmann K obtained funding; Deckmann K, Schmidt P, Nassenstein C, and Perniss A drafted the manuscript; All authors have read and approved the final manuscript.
Supported by University Hospital of Giessen and Marburg (UKGM)-Justus-Liebig-University (JLU)-Cooperation Grant, No. 7/2016 GI; the Else Kröner-Fresenius-Stiftung, No. 2016_A90; and the German Research Foundation, No. 544054869.
Informed consent statement: This report protects the body donors’ privacy and anonymity. The authors ensure that the body name and initials would not be published and that due efforts would be made to conceal his identity. The cadaver described in this case report was a body donor who gave written informed consent during lifetime for the postmortem use of his body for research and education. It was obtained from the body donation program of the Justus-Liebig-University. A release from medical confidentiality obligations was given by the bereaved. This allowed us to retrieve the clinical records from the period of three years before death. The research was performed in accordance with the guidelines from the Declaration of Helsinki.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Klaus Deckmann, Senior Researcher, Institute for Anatomy and Cell Biology, Justus-Liebig-University Giessen, Aulweg 123, Giessen 35392, Hesse, Germany. klaus.deckmann@anatomie.med.uni-giessen.de
Received: January 9, 2025
Revised: March 18, 2025
Accepted: May 7, 2025
Published online: July 27, 2025
Processing time: 196 Days and 2.4 Hours
Core Tip

Core Tip: Diverticulosis, which mainly affects older people, is often associated with diverticulitis. Abnormal peristalsis and increased intraluminal pressure cause the formation of diverticula. During the course “Gross Anatomy,” we found a case of multiple jejunal diverticula. We counted 232 jejunal diverticulum entry sites over a total length of 208 cm of intestine. Here, we showed the correlation between visible changes in the smooth muscle architecture and the microscopic structures, as well as the correlation with previously observed clinical symptoms. These findings notably support the theory that abnormalities in the smooth musculature lead to pathological remodeling of the intestine.