Editorial
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Apr 27, 2025; 17(4): 101066
Published online Apr 27, 2025. doi: 10.4240/wjgs.v17.i4.101066
Pan-immune-inflammation in colon cancer: A prognostic biomarker and the role of tumor location in personalized care
Gaya Spolverato, Giulia Capelli, Floriane Noel, Michele Steindler, Andrew Alexander Gumbs
Gaya Spolverato, Department of Surgery, University of Padova, Padua 35122, Italy
Giulia Capelli, Department of Surgery, ASST Bergamo Est, Bergamo 24068, Lombardy, Italy
Floriane Noel, Michele Steindler, Department of Research, Sibylone, Paris 75002, France
Andrew Alexander Gumbs, Department of Surgery, University of Magdeburg, Magdeburg 39130, Saxony-Anhalt, Germany
Andrew Alexander Gumbs, Department of Surgery, Service de Chirurgie Digestive Minimale Invasive, Hôpital Antoine Béclère, Assistance Publique-Hôpitaux de Paris, Clamart 92140, France
Author contributions: Spolverato G, Capelli G, Noel F, Steindler M, and Gumbs AA contributed to this paper; Gumbs AA designed the overall concept and outline of the manuscript; Spolverato G contributed to the discussion and design of the manuscript; Noel F and Steindler M drafted the manuscript; Spolverato G and Capelli G contributed to manuscript writing, editing, and review of the literature. All authors have read and approved the final manuscript.
Conflict-of-interest statement: No conflicts of interest to report.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Andrew Alexander Gumbs, FACS, MD, MSc, Chief, Full Professor, Department of Surgery, Service de Chirurgie Digestive Minimale Invasive, Hôpital Antoine Béclère, Assistance Publique-Hôpitaux de Paris, 157 Rue de la Porte de Trivaux, Clamart 92140, France. aagumbs@gmail.com
Received: September 3, 2024
Revised: February 14, 2025
Accepted: February 25, 2025
Published online: April 27, 2025
Processing time: 206 Days and 20.6 Hours
Core Tip

Core Tip: A recent study by Wang et al highlights that a high pan-immune inflammation value is associated with worse disease-free survival in left-sided colon cancer, but not in right-sided colon cancer. This suggests that considering tumor location in colorectal cancer prognosis may help identify high-risk patients and more effectively tailor treatment plans.