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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Dec 27, 2025; 17(12): 112841
Published online Dec 27, 2025. doi: 10.4240/wjgs.v17.i12.112841
Published online Dec 27, 2025. doi: 10.4240/wjgs.v17.i12.112841
Impact of statin therapy on postoperative outcomes following colorectal cancer surgery: A systematic review
Sana Mohsin, Misha Hasan, Fatima Mustafa, College of Medicine, Ziauddin University, Karachi 75600, Sindh, Pakistan
Jai Kumar, School of Medicine, Wayne State University, Detroit, MI 48202, United States
Maryam Aleissa, Jasneet S Bhullar, Department of Surgery-Colon and Rectal Surgery, Ascension Providence Hospital, Michigan State University, Southfield, MI 48075, United States
Sarwan Kumar, Department of Internal Medicine, Wayne State University, Detroit, MI 48202, United States
Author contributions: Mohsin S, Hasan M, and Mustafa F contributed to literature search; Mohsin S and Hasan M contributed to conception and administration of the project and manuscript, data curation, extraction, and substantial contribution to drafting of the manuscript; Mustafa F, Kumar J, Aleissa M, Bhullar JS, and Kumar S contributed to reviewing the manuscript; Mustafa F contributed to drafting the manuscript; Kumar J, Aleissa M, Bhullar JS, and Kumar S contributed to revising the manuscript. All authors critically revised the manuscript and provided their final approval.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jasneet S Bhullar, Department of Surgery-Colon and Rectal Surgery, Ascension Providence Hospital, Michigan State University, 16001 West 9 Mile Road, Southfield, MI 48075, United States. drjsbhullar@gmail.com
Received: August 8, 2025
Revised: September 3, 2025
Accepted: October 30, 2025
Published online: December 27, 2025
Processing time: 139 Days and 9.2 Hours
Revised: September 3, 2025
Accepted: October 30, 2025
Published online: December 27, 2025
Processing time: 139 Days and 9.2 Hours
Core Tip
Core Tip: This review evaluates the impact of statin therapy on postoperative outcomes following colorectal cancer surgery. The study focuses on cohort studies to show how statin use, particularly its timing and duration, may affect the risk of anastomotic leaks, surgical site infection, and short-term mortality. Despite conflicting data, a consistent trend toward reduced 30-day mortality was observed. Overall, these findings suggest the potential role of statins in colorectal cancer surgery, however due to the heterogeneity in definitions of statin therapy and limitations of study design there is a need for prospective studies to confirm their role in improving postsurgical outcomes.