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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Dec 27, 2025; 17(12): 112685
Published online Dec 27, 2025. doi: 10.4240/wjgs.v17.i12.112685
Published online Dec 27, 2025. doi: 10.4240/wjgs.v17.i12.112685
Impact of teduglutide on pediatric short bowel syndrome: A systematic review and trial sequential meta-analysis
Pan Jiao, Zhong-Jing Zhang, Ying Jiang, Jun Zhou, Ke-Heng Deng, Wen-Xiang Zhu, Xiang-You Zhao, Zhao-Kun Guo, Department of Pediatric Surgery, Yichang Central People's Hospital Affiliated to China Three Gorges University, Yichang 443003, Hubei Province, China
Author contributions: Jiao P and Guo ZK conceptualized and designed the study; Zhang ZJ drafted the manuscript; Jiang Y, Zhou J searched relevant databases; Deng KH and Zhu WX conducted literature screening and data extraction; Pan J and Zhao XY assessed the risk of bias; Zhang ZJ and Zhou J prepared tables and figures; Pan J resolved discrepancies and revised the manuscript; Guo ZK proofread the manuscript and improved English writing; Pan J is the guarantor for the overall content. All authors read and approved the final manuscript.
Conflict-of-interest statement: The authors declare that they have no competing financial interests or personal relationships that may have influenced the work reported in this study.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhao-Kun Guo, MD, Department of Pediatric Surgery, Yichang Central People's Hospital Affiliated to China Three Gorges University, No. 183 Yiling Road, Yichang 443003, Hubei Province, China. 12893437@qq.com
Received: August 4, 2025
Revised: September 24, 2025
Accepted: October 22, 2025
Published online: December 27, 2025
Processing time: 144 Days and 11.4 Hours
Revised: September 24, 2025
Accepted: October 22, 2025
Published online: December 27, 2025
Processing time: 144 Days and 11.4 Hours
Core Tip
Core Tip: This study evaluates the safety of teduglutide in pediatric short bowel syndrome via systematic review and trial sequential analysis. Three randomized controlled trials (n = 115) show no significant increase in infections or gastrointestinal adverse events, but small sample sizes limit conclusions. Larger, long-term studies are needed.