Copyright
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Dec 27, 2025; 17(12): 111829
Published online Dec 27, 2025. doi: 10.4240/wjgs.v17.i12.111829
Published online Dec 27, 2025. doi: 10.4240/wjgs.v17.i12.111829
Intra-abdominal pressure and procalcitonin for prognosis in patients with severe acute pancreatitis: An etiology-based analysis
Jin-Feng Zhao, Guo-Xing Jin, Xue-Ming Huang, Department of General Surgery, Huzhou Wuxing District People's Hospital, Wuxing District Maternal and Child Health Hospital of Huzhou City, Huzhou 313000, Zhejiang Province, China
Yao Wang, Department of General Surgery, Huzhou First People’s Hospital, Huzhou 313000, Zhejiang Province, China
Author contributions: Zhao JF performed the research, analyzed the data, and wrote the manuscript; Zhao JF and Jin GX designed the research study; Wang Y and Huang XM contributed to the data collection; All authors read and approved the final manuscript.
Supported by Huzhou Science and Technology Bureau Public Welfare Applied Research Project-General Medical and Health Program, No. 2021GY21.
Institutional review board statement: The Ethics Committee of Huzhou Wuxing District People’s Hospital determined that this retrospective study using deidentified data was exempt from full review per institutional guidelines for retrospective research using anonymized data.
Informed consent statement: The requirement for informed consent was waived by the Ethics Committee of Huzhou Wuxing District People’s Hospital because of the retrospective nature of this study and the use of anonymized data, in accordance with national regulations for retrospective research.
Conflict-of-interest statement: All authors report having no relevant conflicts of interest for this article.
Data sharing statement: The datasets generated and analyzed during the current study are available from the corresponding author at tony1128lu@gmail.com upon reasonable request. The data are anonymized, and the risk of identification is low. All data requests will be subject to institutional privacy review.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Guo-Xing Jin, Chief Physician, Department of General Surgery, Huzhou Wuxing District People's Hospital, Wuxing District Maternal and Child Health Hospital of Huzhou City, No. 1599 Dagang Road, Wuxing District, Huzhou 313000, Zhejiang Province, China. tony1128Lu@gmail.com
Received: July 10, 2025
Revised: September 17, 2025
Accepted: October 20, 2025
Published online: December 27, 2025
Processing time: 168 Days and 8.2 Hours
Revised: September 17, 2025
Accepted: October 20, 2025
Published online: December 27, 2025
Processing time: 168 Days and 8.2 Hours
Core Tip
Core Tip: By integrating intra-abdominal pressure and procalcitonin using a machine learning algorithm, this study established a superior prognostic model for severe acute pancreatitis (AP). The core innovation, however, lies in revealing profound etiological heterogeneity. We demonstrated that the correlation between intra-abdominal pressure and procalcitonin and the benefits of guided management are most significant in patients with hypertriglyceridemic AP. These findings advocate for a shift from a uniform approach to an etiology-stratified precision medicine strategy, particularly for the high-risk hypertriglyceridemic AP subgroup.