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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Dec 27, 2025; 17(12): 111714
Published online Dec 27, 2025. doi: 10.4240/wjgs.v17.i12.111714
Published online Dec 27, 2025. doi: 10.4240/wjgs.v17.i12.111714
Analysis of risk factors for disease recurrence after endoscopic submucosal dissection of early esophageal cancer
Yan-Mei Yang, Ting Dai, Ling-Yu Zou, Cheng-Jin Zhao, Department of Gastroenterology, Nantong First People’s Hospital, Southeast University Affiliated Nantong First People’s Hospital, Nantong 226001, Jiangsu Province, China
Co-first authors: Yan-Mei Yang and Ting Dai.
Author contributions: Yang YM, Dai T contributed to conceptualization, data curation, methodology, software, writing original draft; Zou LY contributed to formal analysis, project administration, visualization; Zhao CJ contributed to investigation, supervision, validation, writing, review and editing.
Institutional review board statement: The study was reviewed and approved by Nantong First People’s Hospital, Southeast University Affiliated Nantong First People’s Hospital (No. 2025KT177).
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Cheng-Jin Zhao, MD, Doctor, Department of Gastroenterology, Nantong First People’s Hospital, Southeast University Affiliated Nantong First People’s Hospital, No. 666 Shengli Road, Nantong 226001, Jiangsu Province, China. jackiel1980@163.com
Received: August 1, 2025
Revised: August 23, 2025
Accepted: October 20, 2025
Published online: December 27, 2025
Processing time: 145 Days and 18.5 Hours
Revised: August 23, 2025
Accepted: October 20, 2025
Published online: December 27, 2025
Processing time: 145 Days and 18.5 Hours
Core Tip
Core Tip: The disease recurrence rate after endoscopic submucosal dissection for early esophageal cancer was 14.19%. A low degree of differentiation, infiltration into the submucosa, incomplete tumor resection, and tumor diameter ≥ 2 cm were independent risk factors for postoperative recurrence. Accurate assessment of these risk factors can help inform personalized follow-up strategies and secondary treatment plans to increase patients’ chances of long-term survival.