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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Nov 27, 2025; 17(11): 111973
Published online Nov 27, 2025. doi: 10.4240/wjgs.v17.i11.111973
Published online Nov 27, 2025. doi: 10.4240/wjgs.v17.i11.111973
Factors influencing analysis of the efficacy of probiotics combined with enteral nutrition in postoperative patients with colorectal cancer
Yu Zhang, Jie Wu, Yuan Yuan, Hua Han, Department of Clinical Nutrition, The First People's Hospital of Zunyi (The Third Affiliated Hospital of Zunyi Medical University), Zunyi 563000, Guizhou Province, China
Yong-Sheng Huang, Department of Gastrointestinal Surgery, The First People's Hospital of Zunyi (The Third Affiliated Hospital of Zunyi Medical University), Zunyi 563000, Guizhou Province, China
Author contributions: Zhang Y designed the experiments and conducted clinical data collection; Wu J, Yuan Y and Huang YS performed postoperative follow-up and recorded the data, conducted the collation and statistical analysis; Zhang Y and Han H make critical revisions to important knowledge content; all authors read and approved the final manuscript.
Supported by Zunyi Science and Technology Plan Project, No. Zunshi Kehe HZ Zi (2023) No. 49.
Institutional review board statement: This study was approved by the Ethics Committee of the First People's Hospital of Zunyi.
Informed consent statement: The ethics committee of the institution waived the patient's informed consent.
Conflict-of-interest statement: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Data sharing statement: All data generated or analyzed during this study are included in this published article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hua Han, MM, Department of Clinical Nutrition, The First People's Hospital of Zunyi (The Third Affiliated Hospital of Zunyi Medical University), No. 98 Fenghuang Road, Huichuan District, Zunyi 563000, Guizhou Province, China.
Received: July 15, 2025
Revised: August 13, 2025
Accepted: September 17, 2025
Published online: November 27, 2025
Processing time: 133 Days and 2.3 Hours
Revised: August 13, 2025
Accepted: September 17, 2025
Published online: November 27, 2025
Processing time: 133 Days and 2.3 Hours
Core Tip
Core Tip: This retrospective study identifies key predictors influencing the efficacy of probiotics combined with enteral nutrition in 511 postoperative colorectal cancer patients. Younger age, higher protein intake, balanced gut microbiota (elevated Bifidobacterium, reduced Fusobacterium nucleatum), and improved immune markers independently correlated with better outcomes. These findings highlight modifiable factors—nutritional optimization and microbiota modulation—for enhancing recovery. Multivariate analysis confirmed age, tumor node metastasis stage, protein intake, and microbial composition as significant prognostic indicators.