Zhang Y, Wu J, Yuan Y, Huang YS, Han H. Factors influencing analysis of the efficacy of probiotics combined with enteral nutrition in postoperative patients with colorectal cancer. World J Gastrointest Surg 2025; 17(11): 111973 [DOI: 10.4240/wjgs.v17.i11.111973]
Corresponding Author of This Article
Hua Han, MM, Department of Clinical Nutrition, The First People's Hospital of Zunyi (The Third Affiliated Hospital of Zunyi Medical University), No. 98 Fenghuang Road, Huichuan District, Zunyi 563000, Guizhou Province, China. hanhuahao2009@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Nov 27, 2025 (publication date) through Nov 25, 2025
Times Cited of This Article
Times Cited (0)
Journal Information of This Article
Publication Name
World Journal of Gastrointestinal Surgery
ISSN
1948-9366
Publisher of This Article
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Share the Article
Zhang Y, Wu J, Yuan Y, Huang YS, Han H. Factors influencing analysis of the efficacy of probiotics combined with enteral nutrition in postoperative patients with colorectal cancer. World J Gastrointest Surg 2025; 17(11): 111973 [DOI: 10.4240/wjgs.v17.i11.111973]
World J Gastrointest Surg. Nov 27, 2025; 17(11): 111973 Published online Nov 27, 2025. doi: 10.4240/wjgs.v17.i11.111973
Factors influencing analysis of the efficacy of probiotics combined with enteral nutrition in postoperative patients with colorectal cancer
Yu Zhang, Jie Wu, Yuan Yuan, Yong-Sheng Huang, Hua Han
Yu Zhang, Jie Wu, Yuan Yuan, Hua Han, Department of Clinical Nutrition, The First People's Hospital of Zunyi (The Third Affiliated Hospital of Zunyi Medical University), Zunyi 563000, Guizhou Province, China
Yong-Sheng Huang, Department of Gastrointestinal Surgery, The First People's Hospital of Zunyi (The Third Affiliated Hospital of Zunyi Medical University), Zunyi 563000, Guizhou Province, China
Author contributions: Zhang Y designed the experiments and conducted clinical data collection; Wu J, Yuan Y and Huang YS performed postoperative follow-up and recorded the data, conducted the collation and statistical analysis; Zhang Y and Han H make critical revisions to important knowledge content; all authors read and approved the final manuscript.
Supported by Zunyi Science and Technology Plan Project, No. Zunshi Kehe HZ Zi (2023) No. 49.
Institutional review board statement: This study was approved by the Ethics Committee of the First People's Hospital of Zunyi.
Informed consent statement: The ethics committee of the institution waived the patient's informed consent.
Conflict-of-interest statement: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Data sharing statement: All data generated or analyzed during this study are included in this published article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hua Han, MM, Department of Clinical Nutrition, The First People's Hospital of Zunyi (The Third Affiliated Hospital of Zunyi Medical University), No. 98 Fenghuang Road, Huichuan District, Zunyi 563000, Guizhou Province, China. hanhuahao2009@163.com
Received: July 15, 2025 Revised: August 13, 2025 Accepted: September 17, 2025 Published online: November 27, 2025 Processing time: 132 Days and 23.3 Hours
Abstract
BACKGROUND
Colorectal cancer is a prevalent malignancy with suboptimal postoperative recovery outcomes. Enhancing recovery and prolonging disease-free survival remains a critical challenge. This study investigates factors influencing the efficacy of probiotics combined with enteral nutrition in postoperative patients with colorectal cancer.
AIM
To identify predictors of therapeutic efficacy for probiotics combined with enteral nutrition in postoperative patients with colorectal cancer.
METHODS
A retrospective study was conducted with 511 patients with colorectal cancer who underwent surgery and received probiotics and enteral nutrition from January 2022 to March 2025. Patients were categorized into the “good efficacy group” (n = 279) and “poor efficacy group” (n = 232) based on outcomes observed 3 months post-surgery. Variables assessed included gut microbiota composition, nutritional intake, immune and inflammatory markers, and demographic characteristics.
RESULTS
Patients with favorable outcomes were typically younger, had higher caloric, protein, and fiber intake, and displayed enhanced intestinal mucosal barrier function with elevated levels of Bifidobacterium and Lactobacillus. Immune markers such as immunoglobulin A, immunoglobulin M, immunoglobulin G, and CD4+/ CD8+ T-cell ratios were significantly higher in the good efficacy group. High numbers of Fusobacterium nucleatum and Bacteroides fragilis and levels of tumor necrosis factor-alpha and interleukin-6 were associated with poor efficacy. Multivariate analysis identified age, tumor node metastasis stage, protein intake, and gut microbiota composition as significant predictors of therapeutic success.
CONCLUSION
The efficacy of combining probiotics with enteral nutrition in postoperative patients with colorectal cancer was influenced by age, nutritional intake, microbiota balance, immune status, and inflammatory markers.
Core Tip: This retrospective study identifies key predictors influencing the efficacy of probiotics combined with enteral nutrition in 511 postoperative colorectal cancer patients. Younger age, higher protein intake, balanced gut microbiota (elevated Bifidobacterium, reduced Fusobacterium nucleatum), and improved immune markers independently correlated with better outcomes. These findings highlight modifiable factors—nutritional optimization and microbiota modulation—for enhancing recovery. Multivariate analysis confirmed age, tumor node metastasis stage, protein intake, and microbial composition as significant prognostic indicators.
