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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Oct 27, 2025; 17(10): 111885
Published online Oct 27, 2025. doi: 10.4240/wjgs.v17.i10.111885
Published online Oct 27, 2025. doi: 10.4240/wjgs.v17.i10.111885
Perioperative approach to nephrotoxicity in cytoreductive surgery and hyperthermic intraperitoneal chemotherapy
Şenay Göksu, Department of Anesthesiology and Reanimation, University of Health Sciences, Ümraniye Training and Research Hospital, Istanbul 34764, Türkiye
Özgül Düzgün, Department of Surgical Oncology, University of Health Sciences, Ümraniye Training and Research Hospital, İstanbul 34764, Türkiye
Author contributions: Göksu Ş collected the patients’ clinical data, analyzed the data, and wrote the manuscript; Düzgün Ö contributed to the supervision of the project and to the preparation of the original draft. All authors read and approved the final version of the manuscript.
Institutional review board statement: The Ethics Committee of the University of Health Sciences, İstanbul Ümraniye Training and Research Hospital, approved the study, No. 2025-11.
Informed consent statement: Due to the retrospective nature of the study, informed consent was not obtained from the patients.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: The data that supported the findings of this study are available from the corresponding author upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Şenay Göksu, MD, Department of Anesthesiology and Reanimation, University of Health Sciences, Ümraniye Training and Research Hospital, Adem Yavuz Street, Istanbul 34764, Türkiye. goksust@gmail.com
Received: July 14, 2025
Revised: August 13, 2025
Accepted: September 26, 2025
Published online: October 27, 2025
Processing time: 104 Days and 22.8 Hours
Revised: August 13, 2025
Accepted: September 26, 2025
Published online: October 27, 2025
Processing time: 104 Days and 22.8 Hours
Core Tip
Core Tip: We report an acute kidney injury incidence of 13.7% following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy treatment in patients with peritoneal carcinomatosis. Independent risk factors include cisplatin use, inadequate fluid replacement, vasopressor requirement, and reduced preoperative estimated glomerular filtration rate. The collective findings emphasized the importance of thorough preoperative renal function assessment and personalized perioperative fluid management. Chemotherapy agent selection plays a key role in minimizing renal toxicity. Optimal perioperative care is essential in preventing long-term renal complications.