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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Oct 27, 2025; 17(10): 109359
Published online Oct 27, 2025. doi: 10.4240/wjgs.v17.i10.109359
Published online Oct 27, 2025. doi: 10.4240/wjgs.v17.i10.109359
Cholecystectomy and non-alcoholic fatty liver disease: Exploring the hidden connection and implications
Xue-Yan Liu, Yan Jiao, Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, First Hospital of Jilin University, Changchun 130000, Jilin Province, China
Jing Ma, Department of Emergency ICU, First Hospital of Jilin University, Changchun 130000, Jilin Province, China
Co-first authors: Xue-Yan Liu and Jing Ma.
Author contributions: Liu XY contributed to the writing, editing of the manuscript; Ma J contributed to the literature search; Liu XY and Ma J contributed equally to this article, they are the co-first authors of this manuscript; Jiao Y designed the overall concept and outline of the manuscript and contributed to the discussion and design of the manuscript; and all authors have read and approve the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yan Jiao, Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, First Hospital of Jilin University, No. 1 Xinmin Street, Changchun 130000, Jilin Province, China. lagelangri1@126.com
Received: May 9, 2025
Revised: May 27, 2025
Accepted: September 4, 2025
Published online: October 27, 2025
Processing time: 168 Days and 23.3 Hours
Revised: May 27, 2025
Accepted: September 4, 2025
Published online: October 27, 2025
Processing time: 168 Days and 23.3 Hours
Core Tip
Core Tip: Cholecystectomy, a common surgical treatment for gallbladder diseases, may inadvertently increase the risk of non-alcoholic fatty liver disease due to disrupted bile acid metabolism, gut microbiota dysbiosis, and altered lipid regulation. These metabolic disturbances are especially pronounced in patients with obesity or insulin resistance. This review highlights emerging mechanistic insights and underscores the importance of proactive liver health monitoring and lifestyle intervention following cholecystectomy.