Huang XJ, Zheng X, Wang K. Association between hepatitis B virus markers and liver fibrosis staging in patients with chronic hepatitis B. World J Gastrointest Surg 2025; 17(10): 106414 [DOI: 10.4240/wjgs.v17.i10.106414]
Corresponding Author of This Article
Xiao-Jing Huang, Department of Infection, Hangzhou Linping District First People’s Hospital, No. 369 Yingbin Road, Nanyuan Street, Linping District, Hangzhou 311100, Zhejiang Province, China. 13306521018@163.com
Research Domain of This Article
Infectious Diseases
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Oct 27, 2025 (publication date) through Oct 24, 2025
Times Cited of This Article
Times Cited (0)
Journal Information of This Article
Publication Name
World Journal of Gastrointestinal Surgery
ISSN
1948-9366
Publisher of This Article
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Share the Article
Huang XJ, Zheng X, Wang K. Association between hepatitis B virus markers and liver fibrosis staging in patients with chronic hepatitis B. World J Gastrointest Surg 2025; 17(10): 106414 [DOI: 10.4240/wjgs.v17.i10.106414]
World J Gastrointest Surg. Oct 27, 2025; 17(10): 106414 Published online Oct 27, 2025. doi: 10.4240/wjgs.v17.i10.106414
Association between hepatitis B virus markers and liver fibrosis staging in patients with chronic hepatitis B
Xiao-Jing Huang, Xiao Zheng, Kai Wang
Xiao-Jing Huang, Xiao Zheng, Kai Wang, Department of Infection, Hangzhou Linping District First People’s Hospital, Hangzhou 311100, Zhejiang Province, China
Author contributions: Huang XJ contributed to the conception and design, writing, review, and revision of the manuscript; all authors contributed to the analysis and interpretation of data, acquisition of data (acquired and managed patients), and final approved the manuscript.
Institutional review board statement: This study was approved by the Ethic Committee of Hangzhou Linping District First People’s Hospital.
Informed consent statement: Due to the retrospective and de-identified nature of this study, written informed consent was waived.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Jing Huang, Department of Infection, Hangzhou Linping District First People’s Hospital, No. 369 Yingbin Road, Nanyuan Street, Linping District, Hangzhou 311100, Zhejiang Province, China. 13306521018@163.com
Received: May 16, 2025 Revised: June 17, 2025 Accepted: August 22, 2025 Published online: October 27, 2025 Processing time: 160 Days and 16.6 Hours
Core Tip
Core Tip: By combining three serum biomarkers, hepatitis B core antibody, hepatitis B virus-DNA, and hepatitis B surface antigen, this study proposes a cost-effective, non-invasive diagnostic approach for assessing chronic hepatitis B-related liver fibrosis (LF) staging, providing advantages in operational convenience and repeatability. The multi-parameter model demonstrated superior diagnostic performance without compromising either sensitivity or specificity. Further, a strong correlation of hepatitis B core antibody and hepatitis B virus-DNA with LF progression was determined. Altogether, a promising non-invasive serological tool for LF staging is proposed in this study, providing a cost-effective solution to improve clinical diagnostics and patient care.
