Meta-Analysis
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Nov 27, 2024; 16(11): 3546-3558
Published online Nov 27, 2024. doi: 10.4240/wjgs.v16.i11.3546
Preventive effect of probiotics on infections following colorectal cancer surgery: An umbrella meta-analysis
Yue Han, Yong Wang, Min Guan
Yue Han, Min Guan, Department of Gastrointestinal Surgery, Shandong Provincial Third Hospital, Shandong University, Jinan 250031, Shandong Province, China
Yong Wang, Department of Hepatobiliary Surgery, Shandong Provincial Third Hospital, Shandong University, Jinan 250031, Shandong Province, China
Co-first authors: Yue Han and Yong Wang.
Author contributions: Han Y was responsible for conceptualization, methodology, investigation, writing-original draft, writing-review and editing, visualization; Wang Y was responsible for methodology, investigation, resources, software, formal analysis, data curation, writing original draft, visualization; Guan M was responsible for supervision, methodology, conceptualization, project administration, investigation, writing-review and editing. All authors have read and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Min Guan, PhD, Doctor, Department of Gastrointestinal Surgery, Shandong Provincial Third Hospital, Shandong University, No. 11 Middle Wuyingshan Road, Tianqiao District, Jinan 250031, Shandong Province, China. gmindoc@163.com
Received: May 9, 2024
Revised: August 7, 2024
Accepted: September 9, 2024
Published online: November 27, 2024
Processing time: 174 Days and 2.4 Hours
Core Tip

Core Tip: This meta-analysis of 11 studies involving 11518 colorectal cancer (CRC) patients found that probiotics significantly reduce postoperative infection rates, including surgical site infections, pneumonia, urinary tract infections, bacteremia, and sepsis. Probiotics were particularly effective in preventing these complications, demonstrating minimal efficacy against intra-abdominal, central line, and peritoneal infections. These findings support the integration of probiotics into post-CRC surgery prevention strategies.