Acute pancreatitis and COVID-19: A literature review

doi:10.4240/wjgs.v13.i6.574

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World Journal of Gastrointestinal Surgery

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World J Gastrointest Surg. Jun 27, 2021; 13(6): 574-584
Published online Jun 27, 2021. doi: 10.4240/wjgs.v13.i6.574

Acute pancreatitis and COVID-19: A literature review

Tiago Correia de Sá, Carlos Soares, Mónica Rocha

Tiago Correia de Sá, Carlos Soares, Mónica Rocha, Department of General Surgery, Centro Hospitalar do Tâmega e Sousa, Penafiel 4564-007, Portugal

Author contributions: Correia de Sá T, Soares C, and Rocha M designed the research study and performed the research; Correia de Sá T analyzed the data and wrote the manuscript; All authors have read, reviewed, and approved the final manuscript.

Conflict-of-interest statement: The authors declare no conflicts of interest.

PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.

Corresponding author: Tiago Correia de Sá, MD, Surgeon, Department of General Surgery, Centro Hospitalar do Tâmega e Sousa, Avenida do Hospital Padre Américo 210, Penafiel 4564-007, Portugal. tiago.rc.sa@gmail.com

Received: January 10, 2021
Peer-review started: January 10, 2021
First decision: February 14, 2021
Revised: February 26, 2021
Accepted: June 1, 2021
Article in press: June 1, 2021
Published online: June 27, 2021
Processing time: 158 Days and 20.4 Hours

ARTICLE HIGHLIGHTS

Research background

There is increasing literature connecting acute pancreatitis (AP) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, but whether SARS-CoV-2 can cause AP or is an epiphenomenon remains a subject of debate.

Research motivation

To explore current literature and provide a concise overview of the current evidence as well as possible mechanisms of pancreatic injury in coronavirus disease 2019 (COVID-19) patients.

Research objectives

To provide an overview of current evidence on AP in COVID-19 patients and to promote and enhance future studies on this special subset of patients.

Research methods

Systematic and narrative review of the literature.

Research results

Available studies on AP in COVID-19 patients present important limitations and mechanisms of pancreatic injury are debatable and not completely understood.

Research conclusions

Currently there is insufficient evidence showing that SARS-CoV-2 infection can cause AP and the therapeutic and prognostic significance of AP in COVID-19 patients is largely unknown.

Research perspectives

This is a very important issue, requiring ongoing research.